SynthesisIntensive care medicine2012
Accuracy of plethysmographic indices as predictors of fluid responsiveness in mechanically ventilated adults: a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03009669 (The Application of Pleth Variability Index in Continuous Monitoring Volume Status in Patients Undergoing Intestinal Tumor Surgery), which is not on this map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Application of Pleth Variability Index in Continuous Monitoring Volume Status in Patients Undergoing Intestinal Tumor Surgery
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Non-invasive goal-directed fluid therapy with the pleth variability index (PVI): a systematic review and meta-analysis.Journal of clinical monitoring and computing · 2025Pooled it
- Reliability of pleth variability index in predicting preload responsiveness of mechanically ventilated patients under various conditions: a systematic review and meta-analysis.BMC anesthesiology · 2019Pooled it
- Does stroke volume variation predict fluid responsiveness in children: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany.European journal of anaesthesiology · 2016Guideline
- Accuracy of pleth variability index to predict fluid responsiveness in mechanically ventilated patients: a systematic review and meta-analysis.Journal of clinical monitoring and computing · 2016Pooled it
- Pleth variability index or stroke volume optimization during open abdominal surgery: a randomized controlled trial.BMC anesthesiology · 2018Trial
- Pleth variability index-directed fluid management in abdominal surgery under combined general and epidural anesthesia.Journal of clinical monitoring and computing · 2015Trial
- The pleth variability index as an indicator of the central extracellular fluid volume in mechanically ventilated patients after anesthesia induction: comparison with initial distribution volume of glucose.Medical science monitor : international medical journal of experimental and clinical research · 2014Trial
- Blood Pressure and Pleth Variability Index as Predictors of Tourniquet-Release Hypotension in Elderly Patients Undergoing Total Knee Arthroplasty: A Prospective Observational Study.Life (Basel, Switzerland) · 2026Article
- Variation of perfusion index to evaluate fluid responsiveness during the preload challenge tests: a systematic review and meta-analysis.Annals of intensive care · 2026Article
- Foundations and Advancements in Hemodynamic Monitoring: Part II - Advanced Parameters and Tools.Turkish journal of anaesthesiology and reanimation · 2025Article
- Validity of Pleth Variability Index to Predict Fluid Responsiveness in Patients Undergoing Cervical Spine Surgery in the Modified Prone Position.Medicina (Kaunas, Lithuania) · 2024Article
- [Hemodynamic monitoring in pediatric anesthesia].Die Anaesthesiologie · 2022Review
- Dynamic variables predict fluid responsiveness in pre-school and school children undergoing neurosurgery: a prospective observational study.Translational pediatrics · 2021Article
- A study to evaluate the change in perfusion index as an indicator of successful ultrasound-guided supraclavicular block.Indian journal of anaesthesia · 2021Article
- Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation.Scientific reports · 2021Article
- Fluid responsiveness in the pediatric population.Korean journal of anesthesiology · 2019Review
- Goal-Directed vs Traditional Approach to Intraoperative Fluid Therapy during Open Major Bowel Surgery: Is There a Difference?Anesthesiology research and practice · 2019Article
- Accuracy and trending of non-invasive hemoglobin measurement during different volume and perfusion statuses.Journal of clinical monitoring and computing · 2018Observational
- Prediction of fluid responsiveness in ventilated patients.Annals of translational medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo systematically review the accuracy of the variation in pulse oxymetry plethysmographic waveform amplitude (∆POP) and the Pleth Variability Index (PVI) as predictors of fluid responsiveness in mechanically ventilated adults.
methodsMEDLINE, Scopus and the Cochrane Database of Systematic Reviews were screened for clinical studies in which the accuracy of ∆POP/PVI in predicting the hemodynamic response to a subsequent fluid bolus had been investigated. Random-effects meta-analysis was used to summarize the results. Data were stratified according to the amount of fluid bolus (large vs. small) and to the study index (∆POP vs. PVI).
resultsTen studies in 233 patients were included in this meta-analysis. All patients were in normal sinus rhythm. The pooled area under the receiver operating characteristic curve (AUC) for identification of fluid responders was 0.85 [95 % confidence interval (CI) 0.79-0.92]. Pooled sensitivity and specificity were 0.80 (95 % CI 0.74-0.85) and 0.76 (0.68-0.82), respectively. No heterogeneity was found within studies with the same amount of fluid bolus, nor between studies on ∆POP and those on PVI. The AUC was significantly larger in studies with a large bolus amount than in those with a small bolus [0.92 (95 % CI 0.87-0.96) vs. 0.70 (0.62-0.79); p < 0.0001]. Sensitivity and specificity were also higher in studies with a large bolus [0.84 (95 % CI 0.77-0.90) vs. 0.72 (0.60-0.82) (small bolus), p = 0.08 and 0.86 (95 % CI 0.75-0.93) vs. 0.68 (0.56-0.77) (small bolus), p = 0.02], respectively.
conclusionsBased on our meta-analysis, we conclude that ∆POP and PVI are equally effective for predicting fluid responsiveness in ventilated adult patients in sinus rhythm. Prediction is more accurate when a large fluid bolus is administered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.