ArticleGastrointestinal endoscopy2012
Focal endoscopic mucosal resection before radiofrequency ablation is equally effective and safe compared with radiofrequency ablation alone for the eradication of Barrett's esophagus with advanced neoplasia.
Article in Gastrointestinal endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Measuring Barrett's Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment.Digestive diseases and sciences · 2019Article
- Treatment of high-grade dysplasia and intramucosal carcinoma using radiofrequency ablation or endoscopic mucosal resection + radiofrequency ablation: Meta-analysis and systematic review.World journal of gastrointestinal endoscopy · 2019Article
- Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.Gastroenterology · 2018Review
- Endotherapy in case of relapse of neoplastic Barrett's esophagus after successful initial endoscopic resection.Surgical endoscopy · 2017Article
- Evolving management of metaplasia and dysplasia in Barrett's epithelium.World journal of gastroenterology · 2016Review
- Non-radical, stepwise complete endoscopic resection of Barrett's epithelium in short segment Barrett's esophagus has a low stricture rate.Endoscopy international open · 2016Article
- Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation Registry.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2016Article
- Current Controversies in Radiofrequency Ablation Therapy for Barrett's Esophagus.Current treatment options in gastroenterology · 2016Article
- Outcomes of Radiofrequency Ablation for Dysplastic Barrett's Esophagus: A Comprehensive Review.Gastroenterology research and practice · 2016Review
- Endoscopic resection of gastric and esophageal cancer.Gastroenterology report · 2015Review
- Effects of the Learning Curve on Efficacy of Radiofrequency Ablation for Barrett's Esophagus.Gastroenterology · 2015Article
- Endoscopic treatments for dysplastic Barrett's esophagus: resection, ablation, what else?World journal of surgery · 2015Review
- Treatment of dysplastic Barrett's Oesophagus in lower volume centres after structured training.World journal of gastrointestinal endoscopy · 2015Article
- Recurrent intestinal metaplasia after radiofrequency ablation for Barrett's esophagus: endoscopic findings and anatomic location.Gastrointestinal endoscopy · 2015Article
- Radiofrequency ablation for Barrett's-associated intramucosal carcinoma: a multi-center follow-up study.Surgical endoscopy · 2014Article
- Ablative therapy for esophageal dysplasia and early malignancy: focus on RFA.BioMed research international · 2014Review
- Managing Barrett's esophagus with radiofrequency ablation.Gastroenterology report · 2013Article
- Barrett oesophagus: Is RFA the overall answer to all Barrett oesophagus issues?Nature reviews. Gastroenterology & hepatology · 2013Article
- Barrett's esophagus: review of diagnosis and treatment.Gastroenterology report · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEMR is commonly performed before radiofrequency ablation (RFA) for nodular dysplastic Barrett's esophagus (BE).
objectiveTo determine the efficacy and safety of EMR before RFA for nodular BE with advanced neoplasia (high-grade dysplasia [HGD] or intramucosal carcinoma [IMC]).
designRetrospective study.
settingUniversity of North Carolina Hospitals, from 2006 to 2011. PATIENTS: 169 patients with BE with advanced neoplasia: 65 patients treated with EMR and RFA for nodular disease and 104 patients treated with RFA alone for nonnodular disease.
interventionsEMR, RFA. MAIN OUTCOME MEASUREMENTS: Efficacy (complete eradication of dysplasia, complete eradication of intestinal metaplasia, total treatment sessions, RFA treatment sessions), safety (stricture formation, bleeding, and hospitalization).
resultsEMR followed by RFA achieved complete eradication of dysplasia and complete eradication of intestinal metaplasia in 94.0% and 88.0% of patients, respectively, compared with 82.7% and 77.6% of patients, respectively, in the RFA-only group (P = .06 and P = .13, respectively). The complication rates between the 2 groups were similar (7.7% vs 9.6%, P = .79). Strictures occurred in 4.6% of patients in the EMR-before-RFA group. compared with 7.7% of patients in the RFA-only group (P = .53). LIMITATIONS: Retrospective study at a tertiary-care referral center.
conclusionIn patients treated with EMR before RFA for nodular BE with HGD or IMC, no differences in efficacy and safety outcomes were observed compared with RFA alone for nonnodular BE with HGD or IMC. EMR followed by RFA is safe and effective for patients with nodular BE and advanced neoplasia.
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