ArticleGastrointestinal endoscopy2012
Sex and racial disparities in duodenal biopsy to evaluate for celiac disease.
Article in Gastrointestinal endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Guideline
- ACG clinical guidelines: diagnosis and management of celiac disease.The American journal of gastroenterology · 2013Guideline
- Celiac Disease: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Strategies.Digestive diseases and sciences · 2026Review
- Gaps and Disparities in Celiac Disease Screening: A Nationwide Analysis of a High-Risk Pediatric Population.Digestive diseases and sciences · 2026Article
- Adherence to guidelines, pitfalls, and emerging technologies in endoscopic practice for celiac disease: a nationwide SIGENP survey.European journal of pediatrics · 2026Article
- Prevalence and Predictors of Persistent Celiac Disease Antibody Positivity During Follow-Up.Digestive diseases and sciences · 2026Article
- Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature.Medicina (Kaunas, Lithuania) · 2026Review
- Racial and Ethnic Differences in the Clinical Presentation of Celiac Disease in the United States: A Multi-institutional Retrospective Analysis.Gastro hep advances · 2026Review
- Delay in Celiac Disease Diagnosis Among Patients with High-Risk Screening Conditions: Results from a United States Claims Database.Journal of clinical medicine · 2025Article
- Article
- Celiac disease symptom profiles and their relationship to gluten-free diet adherence, mental health, and quality of life.BMC gastroenterology · 2024Observational
- Black Patients Are More Likely to Have Negative Serologies With Celiac Consistent Histology in a Southeast US Tertiary Center.Gastro hep advances · 2024Review
- Current Diagnostic Algorithms May Fail to Identify Black Americans With Celiac Disease.Gastro hep advances · 2024Article
- Celiac Disease Presenting in a Community-Based Gastroenterology Practice: Obesity and Bone Disease Are Common.Digestive diseases and sciences · 2023Article
- Celiac Disease in the Elderly.Current treatment options in gastroenterology · 2022Article
- Compliance with Gluten Free Diet Is Associated with Better Quality of Life in Celiac Disease.Nutrients · 2022Article
- AGA Technical Review on Gastrointestinal Evaluation of Iron Deficiency Anemia.Gastroenterology · 2020Review
- Rates of Duodenal Biopsy During Upper Endoscopy Differ Widely Between Providers: Implications for Diagnosis of Celiac Disease.Journal of clinical gastroenterology · 2019Article
- Red Spot Lesions in the Duodenal Bulb Are a Highly Specific Endoscopic Sign of Celiac Disease: A Prospective Study.Journal of pediatric gastroenterology and nutrition · 2019Article
- Coeliac disease: to biopsy or not?Nature reviews. Gastroenterology & hepatology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCeliac disease (CD) is common but underdiagnosed in the United States. Serological screening studies indicate that, although CD occurs at the same frequency in both sexes, women are diagnosed more frequently than men (2:1). CD is less frequently diagnosed among black patients, though the seroprevalence in this group is not known.
objectiveTo measure the rates of duodenal biopsy during EGD for symptoms consistent with CD.
designRetrospective cohort study.
settingClinical Outcomes Research Initiative National Endoscopy Database, spanning the years 2004 through 2009. PATIENTS: Adults undergoing EGD for the indication of diarrhea, anemia, iron deficiency, or weight loss, in which the endoscopic appearance of the upper GI tract was normal. MAIN OUTCOME MEASUREMENT: Performance of duodenal biopsy.
resultsOf 13,091 individuals (58% female patients, 9% black patients) who met the inclusion criteria, duodenal biopsy was performed in 43%, 45% of female patients and 39% of male patients (P < .0001). Black patients underwent duodenal biopsy in 28% of EGDs performed compared with 44% for white patients (P < .0001). On multivariate analysis, male sex (odds ratio [OR] 0.81; 95% CI, 0.75-0.88), older age (OR for 70 years and older compared with 20-49 years, 0.51; 95% CI, 0.46-0.57), and black patients (OR 0.55; 95% CI, 0.48-0.64) were associated with decreased odds of duodenal biopsy. LIMITATIONS: Lack of histopathologic correlation with CD prevalence.
conclusionsIn this multiregional endoscopy database spanning the period from 2004 through 2009, rates of duodenal biopsy increased modestly over time, but overall remained low in patients with possible clinical indications for biopsy. Nonperformance of duodenal biopsy during endoscopy may be contributing to the underdiagnosis of CD in the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.