ArticleAlzheimer disease and associated disorders
The demographic and medical correlates of plasma aβ40 and aβ42.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2018Trial
- Emerging nano-derived therapy for the treatment of dementia: a comprehensive review.Drug delivery and translational research · 2026Review
- An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD.Clinical epigenetics · 2024Article
- Article
- Culture, Ethnicity, and Level of Education in Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Plasma metabolomics of presymptomatic PSEN1-H163Y mutation carriers: a pilot study.Annals of clinical and translational neurology · 2021Article
- The Role of Age on Beta-AmyloidFrontiers in aging neuroscience · 2021Article
- Plasma amyloid β levels in Alzheimer's disease and cognitively normal controls in Syrian population.Medical journal of the Islamic Republic of Iran · 2021Article
- Sleep Disturbance is Associated With Higher Plasma Aβ Levels in Cognitively Normal Adults-A Population-Based Cross-Sectional Study.Frontiers in aging neuroscience · 2020Article
- The Role of Physical Fitness in Cognitive-Related Biomarkers in Persons at Genetic Risk of Familial Alzheimer's Disease.Journal of clinical medicine · 2019Article
- The clinical significance of plasma clusterin and Aβ in the longitudinal follow-up of patients with Alzheimer's disease.Alzheimer's research & therapy · 2017Article
- Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer's disease.Scientific reports · 2017Article
- Plasma Levels of Aβ42 and Tau Identified Probable Alzheimer's Dementia: Findings in Two Cohorts.Frontiers in aging neuroscience · 2017Article
- The Correlation Study between Plasma Aβ Proteins and Cerebrospinal Fluid Alzheimer's Disease Biomarkers.Dementia and neurocognitive disorders · 2016Article
- Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.Current HIV research · 2016Article
- Age and its association with low insulin and high amyloid-β peptides in blood.Journal of Alzheimer's disease : JAD · 2016Article
- Association between cell-bound blood amyloid-β(1-40) levels and hippocampus volume.Alzheimer's research & therapy · 2014Article
- Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker.Alzheimer's research & therapy · 2013Review
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Plasma amyloid β-42 (Aβ42) and Aβ42/Aβ40 are increasingly recognized as biomarkers for dementia, with low levels indicating increased risk. Little is known about the demographic and medical correlates of plasma Aβ40 or Aβ42. In 997 community-dwelling, nondemented older adults from the Health, Aging, and Body Composition Study, we determined the cross-sectional association between a wide range of demographic and medical variables with Aβ40 and Aβ42. In multivariate stepwise linear regression models, Aβ40 was significantly associated with race (β=-14.70, F=22.01, P<0.0001), age (β=1.34, F=6.39, P=0.01), creatinine (β=52.91, F=151.77, P<0.0001), and the serum brain-derived neurotrophic factor (β=-0.0004, F=7.34, P=0.007); Aβ42 was significantly associated with race (β=-3.72, F=30.83, P<0.0001), sex (β=1.39, F=4.32, P=0.04), education (β=1.50, F=4.78, P=0.03), apolipoprotein E e4 genotype (β=-2.82, F=16.57, P<0.0001), and creatinine (β=9.32, F=120.09, P<0.0001). These correlates should be considered as potential confounders in future studies investigating plasma Aβ as a biomarker of dementia. Understanding fully how these correlates mediate or modify the association between plasma Aβ and dementia will be a fundamental step in determining the biological pathways through which plasma Aβ40 and Aβ42 are associated with dementia, and in determining their full potential as biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.