ReviewCurrent opinion in pediatrics2012
Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Review in Current opinion in pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 101 citations in OpenAlex.
- Ultrasound features for pediatric testicular lesions: 20 years of ultrasound practice interpreted through the 2022 WHO Classification.Quantitative imaging in medicine and surgery · 2026Article
- A urologic manifestation of carney complex: Bilateral Sertoli tumors and scrotal myxoma in an adolescent male.Urology case reports · 2026Article
- Advances in non-germ cell tumours of the testis: focus on new molecular developments in sex cord-stromal tumours.Histopathology · 2026Review
- The value of ultrasound texture analysis in the diagnosis of pathological types of primary testicular tumours in adults.BMC cancer · 2025Article
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- 3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization.Advanced healthcare materials · 2025Article
- Progress report: Peutz-Jeghers syndrome.Familial cancer · 2024Review
- Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review.Virchows Archiv : an international journal of pathology · 2024Review
- [Fundamentals in the pathology of testicular tumours].Pathologie (Heidelberg, Germany) · 2024Article
- Bilateral large cell calcifying Sertoli cell tumours: A testicular preservation approach in a young male.Urology case reports · 2023Article
- [Prepubertal gynecomastia at the debut of hereditary tumors predisposition syndrome (clinical case reports)].Problemy endokrinologii · 2023Article
- Loss of liver kinase B1 in human seminoma.Frontiers in oncology · 2023Article
- A 14-Year-Old Saudi Boy with Gynecomastia, Cushing Syndrome, Large-Cell Calcifying Sertoli Cell Tumor of the Testis, and Carney Complex.The American journal of case reports · 2022Article
- The value of contrast-enhanced ultrasonography in the diagnosis of primary testicular non-neoplastic and neoplastic lesions in adults.BMC urology · 2022Article
- Peutz-Jeghers syndrome: Skin manifestations and endocrine anomalies (Review).Experimental and therapeutic medicine · 2021Review
- Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.The Journal of clinical investigation · 2021Article
- Molecular mechanisms underlying AMH elevation in hyperoestrogenic states in males.Scientific reports · 2020Article
- Case - A tale of two boys: An atypical cause of pubertal precocity.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- An Unusual Presentation of Carney ComplexJournal of clinical research in pediatric endocrinology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
purpose of reviewThe aim of this review is to describe the clinical, biochemical, radiographic, histological, and functional characteristics of large-cell calcifying Sertoli cell tumors of the testes (LCCSCTs). We describe the two main syndromes associated with these tumors: Peutz-Jeghers syndrome (PJS) caused mainly by mutations in the STK11 (aka LKB1) gene, which encodes a serine-threonine kinase, and Carney complex (CNC), which is most often caused by PRKAR1A mutations, the gene encoding regulatory subunit type 1 of protein kinase A. RECENT
findingsRelatively few patients have been reported in the literature with LCCSCTs. In children they often present as prepubertal and/or peripubertal gynecomastia. Although these tumors are very rare, they occur with higher frequency among patients with PJS and CNC. Orchiectomy was often performed in the past; however, these tumors are overwhelmingly benign and, unless there are significant hormonal changes or pain and/or mass effects, there is no need for surgery. Tumors that lead to hyperestrogenemia may be treated efficiently with aromatase inhibitors; any change in appearance should prompt evaluation for malignancy. SUMMARY: The detection of LCCSCTs may point to an underlying genetic multiple neoplasia syndrome such as PJS or CNC. Surgery is rarely indicated and aromatase inhibitors constitute an effective treatment for those cases that are associated with gynecomastia and/or advanced skeletal age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.