ArticleRespiratory physiology & neurobiology2012
Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction.
Article in Respiratory physiology & neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reduced biomechanical models for precision-cut lung-slice stretching experiments.Journal of mathematical biology · 2021Article
- Dynamics of airway response in lung microsections: a tool for studying airway-extra cellular matrix interactions.Journal of biomedical science · 2016Review
- Influence of parenchymal heterogeneity on airway-parenchymal interdependence.Respiratory physiology & neurobiology · 2013Article
- Airway-parenchymal interdependence in the lung slice.Respiratory physiology & neurobiology · 2013Article
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4 authors.
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Abstract
Airway hyper-responsiveness (AHR), a hallmark of asthma, is a highly complex phenomenon characterised by multiple processes manifesting over a large range of length and time scales. Multiscale computational models have been derived to embody the experimental understanding of AHR. While current models differ in their derivation, a common assumption is that the increase in parenchymal tethering pressure P(teth) during airway constriction can be described using the model proposed by Lai-Fook (1979), which is based on intact lung experimental data for elastic moduli over a range of inflation pressures. Here we reexamine this relationship for consistency with a nonlinear elastic material law that has been parameterised to the pressure-volume behaviour of the intact lung. We show that the nonlinear law and Lai-Fook's relationship are consistent for small constrictions, but diverge when the constriction becomes large.
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