ArticleAlcohol (Fayetteville, N.Y.)2012
Association of genetic copy number variations at 11 q14.2 with brain regional volume differences in an alcohol use disorder population.
Article in Alcohol (Fayetteville, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- A moderated mediation model in assessing links between rumination, emotional reactivity, and suicidal risk in alcohol use disorder.Frontiers in psychiatry · 2025Article
- Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury.International journal of molecular sciences · 2023Review
- Neuroimaging in alcohol use disorder: From mouse to man.Journal of neuroscience research · 2022Review
- The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.Frontiers in aging neuroscience · 2018Review
- Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.Alcohol research : current reviews · 2017Review
- Genetics of structural connectivity and information processing in the brain.Brain structure & function · 2016Article
- Blind Source Separation for Unimodal and Multimodal Brain Networks: A Unifying Framework for Subspace Modeling.IEEE journal of selected topics in signal processing · 2016Article
- A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence.Scientific reports · 2016Article
- Endophenotypes for Alcohol Use Disorder: An Update on the Field.Current addiction reports · 2015Article
- The IFNγ-PKR pathway in the prefrontal cortex reactions to chronic excessive alcohol use.Alcoholism, clinical and experimental research · 2015Article
- Association between copy number variation losses and alcohol dependence across African American and European American ethnic groups.Alcoholism, clinical and experimental research · 2014Article
- Structural and microstructral imaging of the brain in alcohol use disorders.Handbook of clinical neurology · 2014Review
- A review of multivariate analyses in imaging genetics.Frontiers in neuroinformatics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This study investigates the relationship between genetic copy number variations and brain volume differences in an alcohol use disorder (AUD) population. We hypothesized that copy number variations may influence subject's risk for alcohol use disorders through variations in regional gray and white matter brain volumes. Since genetic influences upon behavior are the result of many complicated interactions we focus on differences in brain volume as a putative intermediate phenotype between genetic variation and behavior. Copy number variation, alcohol use assessments and brain structural magnetic resonance images from 283 subjects, 199 male and 84 females who were enrolled in two AUD studies were obtained and analyzed using a combination of the Freesurfer image analysis suite and independent component analysis. Because brain volume varies by age we compared participant's volume variation with that derived from a control cohort of 75 subjects. In addition we also regressed out the possible brain volume changes induced by long term alcohol consumption. Small cerebral cortex, cerebellar and caudate along with large cerebral white matter and 5th ventricle volumes are shown to be significantly associated with increased AUD severity. When these volume variations are compared with control subject volumes; the variations seen in subjects with AUD are markedly different from normal aging effects. CNVs at 11 q14.2 are marginally (p < 0.05 uncorrected) correlated with such brain volume variations and the correlation holds true after controlling for long-term alcohol consumption; deletion carriers have smaller cerebral cortex, cerebellar, caudate and larger cerebral white matter and 5th ventricle volumes than insertion carriers or subjects with no variation in this region. Similarly, deletion carriers also demonstrate higher AUD severity scores than insertion carriers or subjects with no variation. The results presented here suggest that copy number variation and in particular the variation at chromosome 11 q14.2 may have an impact in brain volume variation, potentially influencing AUD behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.