ArticleCritical care medicine2012
Body mass index and acute kidney injury in the acute respiratory distress syndrome.
Article in Critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis.Critical care (London, England) · 2017Pooled it
- Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials.Critical care (London, England) · 2015Pooled it
- Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation.Annals of intensive care · 2026Article
- A risk-score prediction of postoperative acute kidney injury following lung transplantation: a retrospective cohort study.Journal of cardiothoracic surgery · 2025Article
- Obesity and mortality in KDIGO stage 3 acute kidney injury: a machine learning-driven retrospective cohort study.BMC nephrology · 2025Article
- Impact of early acute kidney injury on 30-day mortality in intensive care unit patients with chronic obstructive pulmonary disease: a retrospective study using MIMIC-IV.Journal of thoracic disease · 2025Article
- Short- and long-term outcomes and 15-year time trends of kidney replacement therapy in critically ill patients with obesity: an observational cohort.Intensive care medicine · 2025Observational
- Causes and Clinical Outcomes of Acute Kidney Injury After Cardiac Arrest: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Epidemiological risk factors for acute kidney injury outcomes in hospitalized adult patients: a multicenter cohort study.Clinical kidney journal · 2025Article
- Assessing the Impact of the Prone Position on Acute Kidney Injury.Journal of clinical medicine · 2025Article
- Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury.Renal failure · 2024Article
- Association of Neighborhood Social Determinants of Health with Acute Kidney Injury during Hospitalization.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- VV-ECMO in critical COVID-19 obese patients: a cohort study.Journal of anesthesia, analgesia and critical care · 2024Article
- Impact of obesity on outcomes of patients with acute respiratory distress syndrome: a retrospective analysis of a large clinical database.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Early Sepsis-Associated Acute Kidney Injury and Obesity.JAMA network open · 2024Article
- Temporal Relationship and Clinical Outcomes of Acute Kidney Injury Following Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.Critical care explorations · 2024Review
- Article
- Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia.Frontiers in nephrology · 2024Article
- Impact of obesity on outcomes after surgical stabilization of multiple rib fractures: Evidence from the US nationwide inpatient sample.PloS one · 2024Article
- Obesity and Acute Kidney Injury in Patients with ST-Elevation Myocardial Infarction.Journal of clinical medicine · 2023Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesObesity is increasingly encountered in intensive care units but the relationship between obesity and acute kidney injury is unclear. We aimed to evaluate whether body mass index was associated with acute kidney injury in the acute respiratory distress syndrome and to examine the association between acute kidney injury and mortality in patients with and without obesity.
designRetrospective study.
settingMassachusetts General Hospital and Beth Israel Deaconess Medical Center. PATIENTS: Seven hundred fifty-one patients with acute respiratory distress syndrome.
interventionsNone. MEASUREMENTS AND MAIN
resultsAcute kidney injury was defined as meeting the "Risk" category according to modified Risk, Injury, Failure, Loss, End-stage criteria based on creatinine and glomerular filtration rate because urine output was only available on the day of intensive care unit admission. Body mass index was calculated from height and weight at intensive care unit admission. The prevalence of acute kidney injury increased significantly with increasing weight (p = .01). The odds of acute kidney injury were twice in obese and severely obese patients compared to patients with normal body mass index, after adjusting for predictors of acute kidney injury (age, diabetes, Acute Physiology and Chronic Health Evaluation III, aspiration, vasopressor use, and thrombocytopenia [platelets ≤ 80,000/mm]). After adjusting for the same predictors, body mass index was significantly associated with acute kidney injury (odds ratio(adj) 1.20 per 5 kg/m increase in body mass index, 95% confidence interval 1.07-1.33). On multivariate analysis, acute kidney injury was associated with increased acute respiratory distress syndrome mortality (odds ratio(adj) 2.76, 95% confidence interval 1.72-4.42) whereas body mass index was associated with decreased mortality (odds ratio(adj) 0.81 per 5 kg/m increase in body mass index, 95% confidence interval 0.71-0.93) after adjusting for mortality predictors.
conclusionsIn acute respiratory distress syndrome patients, obesity is associated with increased development of acute kidney injury, which is not completely explained by severity of illness or shock. Although increased body mass index is associated with decreased mortality, acute kidney injury remained associated with higher mortality even after adjusting for body mass index.
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