ArticleGeneral and comparative endocrinology2012
Estrogen receptor mRNA expression patterns in the liver and ovary of female rainbow trout over a complete reproductive cycle.
Article in General and comparative endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 65 citations in OpenAlex.
- Transcriptomic Response of the Ovarian Follicle Complex in Post-Vitellogenic Rainbow Trout to 17α,20β-Dihdroxy-4-pregnen-3-one In Vitro.International journal of molecular sciences · 2024Article
- Season affects the estrogen system and the immune response of common carp.Fish physiology and biochemistry · 2024Article
- Distribution and expression of GnRH 1, kiss receptor 2, and estradiol α and ß receptors in the anterior brain of females of Chirostoma humboldtianum.Fish physiology and biochemistry · 2021Article
- Metabolome and Transcriptome Analysis of Liver and Oocytes ofFrontiers in genetics · 2021Article
- Transcriptional Activity of an Estrogen Receptor β Subtype in the MedakaDevelopment & reproduction · 2019Article
- Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver.International journal of molecular sciences · 2019Review
- REGULATION OF REPRODUCTIVE PROCESSES WITH DYNAMIC ENERGY BUDGETS.Functional ecology · 2019Article
- Involvement of Estrogen and Its Receptors in Morphological Changes in the Eyes of the Japanese Eel,Cells · 2019Article
- Elevated plasma triglycerides and growth rate are early indicators of reproductive status in post-spawning female steelhead trout (Conservation physiology · 2019Article
- A Computational Model of the Rainbow Trout Hypothalamus-Pituitary-Ovary-Liver Axis.PLoS computational biology · 2016Article
- Article
- Bridging the gap from screening assays to estrogenic effects in fish: potential roles of multiple estrogen receptor subtypes.Environmental science & technology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Estrogens are critical hormones involved in reproduction and need to bind to estrogen receptors in target organs for biological activity. Fishes have two distinct estrogen receptor subtypes, alpha (α) and beta (β), with variable combinations of additional isoforms of each subtype dependent on the history of genome duplication within a taxon. The comparative expression patterns of estrogen receptor isoforms during the female reproductive cycle will provide important insights into the unique function and importance of each. The purpose of this study was to measure the mRNAs for the four estrogen receptor isoforms (erα1, erα2, erβ1, erβ2) in the liver and ovary of adult, female rainbow trout over the course of an annual reproductive cycle. The expression of estrogen receptor mRNA isoforms was measured by quantitative real-time RT-PCR. Several reproductive indices (gonadosomatic index, maximum oocyte diameter, plasma estradiol-17β, plasma vitellogenin, and ovulation) were also quantified for comparison and used in a correlation analysis to examine any inter-relationships. Of the four isoforms, the expression of erα1 was highest in the liver, and had a significant positive correlation with liver erβ1 expression. Liver expression of erα2 mRNA was the lowest, but showed a significant positive correlation with maximum oocyte diameter in the ovary. The pattern of the erβ isoforms in liver was one of initially elevated mRNA expression followed by a gradual decrease as reproductive development proceeded. In the ovary the erβ1 isoform had the highest mRNA expression of all estrogen receptor isoforms, at the beginning of the reproductive cycle, but then decreased afterward. Both ovarian erβ isoforms had a significant positive correlation with one another. In contrast, erα2 mRNA expression showed a high maximum level in the ovary near the end of the cycle along with a significant positive correlation with plasma estradiol-17β levels; the highest gonadosomatic indices, maximum oocyte diameter, and vitellogenin levels occurred then too.
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