ArticleBMC research notes2012
A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed.
- Otitis media: recent advances in otitis media vaccine development and model systems.Frontiers in microbiology · 2024Review
- Comparative Genomic Analysis of the Human PathogenFrontiers in cellular and infection microbiology · 2022Article
- Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics.Chemical reviews · 2021Review
- Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Article
- Factors affecting sound energy absorbance in acute otitis media model of chinchilla.Hearing research · 2017Article
- Dynamic property changes in stapedial annular ligament associated with acute otitis media in the chinchilla.Medical engineering & physics · 2017Article
- Morphological changes in the round window membrane associated with Haemophilus influenzae-induced acute otitis media in the chinchilla.International journal of pediatric otorhinolaryngology · 2016Article
- From Homodimer to Heterodimer and Back: Elucidating the TonB Energy Transduction Cycle.Journal of bacteriology · 2015Article
- Dynamic Properties of Tympanic Membrane in a Chinchilla Otitis Media Model Measured With Acoustic Loading.Journal of biomechanical engineering · 2015Article
- Factors affecting loss of tympanic membrane mobility in acute otitis media model of chinchilla.Hearing research · 2014Article
- Comparison of transcription of the Haemophilus influenzae iron/heme modulon genes in vitro and in vivo in the chinchilla middle ear.BMC genomics · 2013Article
- The role of the RNA chaperone Hfq in Haemophilus influenzae pathogenesis.BMC microbiology · 2013Article
- Signature-tagging of a bacterial isolate demonstrates phenotypic variability of the progeny in vivo in the absence of defined mutations.Journal of microbiological methods · 2012Article
- Haemophilus influenzae OxyR: characterization of its regulation, regulon and role in fitness.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundHaemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient.
methodsAn insertional mutation in tonB was constructed and the impact of the mutation on virulence and fitness in a chinchilla model of otitis media was determined. The tonB insertion mutant strain was significantly impacted in both virulence and fitness as compared to the wildtype strain in this model.
conclusionsThe tonB gene of H. influenzae is required for the establishment and maintenance of middle ear infection in this chinchilla model of bacterial disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.