Evidence map›Paper›PMID 22731712›Full record

ReviewAnnals of the New York Academy of Sciences2012

Zonulin, regulation of tight junctions, and autoimmune diseases.

Alessio Fasano

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03042923 (Intestinal Permeability and Endometriosis), which is not on this map. Cited by 209 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 5 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03042923 completednot on this mapstarted 2016, after this paper: background citation

Intestinal Permeability and Endometriosis

TypeobservationalSponsorUniversity of TennesseeRan2016 to 2019Enrolled46ConditionsEndometriosisArmslactulose:mannitol (L:M) oral challenge
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 5 syntheses or guidelines pooled it, 342 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Review
  15. Article
  16. Review
  17. Observational
  18. Review
  19. Review
  20. Article

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alessio FasanoMucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland, USA. afasano@mbrc.umaryland.edu
University of Maryland, Baltimore · US

Funding

Zot, Zonulin, and Pathophysiology of Intestinal Tight JunctionsR01DK048373 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FASANO, ALESSIO · 1996 to 2015
$4.4M
Timing of Gluten Intake In Infant Nutrition and Risk of Celiac Disease AutoimmuniR21DK078699 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FASANO, ALESSIO · 2008 to 2009
$413k
NIDDK NIH HHS DK-078699NIDDK NIH HHS DK-48373NIDDK NIH HHS R01 DK048373NIDDK NIH HHS R21 DK078699
6 · The paper itself

Abstract

Recent studies indicate that besides digestion and absorption of nutrients and water and electrolytes homeostasis, another key function of the intestine is to regulate the trafficking of environmental antigens across the host mucosal barrier. Intestinal tight junctions (TJs) create gradients for the optimal absorption and transport of nutrients and control the balance between tolerance and immunity to nonself antigens. To meet diverse physiological challenges, intestinal epithelial TJs must be modified rapidly and in a coordinated fashion by regulatory systems that orchestrate the state of assembly of the TJ multiprotein network. While considerable knowledge exists about TJ ultrastructure, relatively little is known about their physiological and pathophysiological regulation. Our discovery of zonulin, the only known physiologic modulator of intercellular TJs described so far, has increased our understanding of the intricate mechanisms that regulate the intestinal epithelial paracellular pathway and has led us to appreciate that its upregulation in genetically susceptible individuals leads to autoimmune diseases.

Indexed as

Amino Acid SequenceAutoimmune DiseasesCholera ToxinGliadinHaptoglobinsHumansIntestinal MucosaMolecular Sequence DataProtein PrecursorsTight JunctionsCholera ToxinGliadinHaptoglobinsProtein Precursorszonulin

Identifiers

PMID22731712
PMCPMC3384703
OpenAlexW2110854995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.