ArticleJournal of women's health (2002)2012
Changes in iron measures over menopause and associations with insulin resistance.
Article in Journal of women's health (2002), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- m6A RNA modifications in neurosystem genes as early markers for osteoporosis with iron accumulation.Molecular biology reports · 2026Article
- Accelerated increase in ferritin levels during menopausal transition as a marker of metabolic health.Scientific reports · 2025Article
- The Prevalence of Vitamin B12, Hemoglobin, and Ferritin Deficiency in Patients with Morbid Obesity and Changes in their Blood Levels after Bariatric Surgery.International journal of preventive medicine · 2025Article
- Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis.Biological trace element research · 2024Article
- Review
- Alterations of Hepcidin and Iron Markers Associated with Obesity and Obesity-related Diabetes in Gambian Women.Wellcome open research · 2024Article
- Association of the systemic immune-inflammation index with anemia: a population-based study.Frontiers in immunology · 2024Article
- Synergistic anti-osteoporosis effects ofFrontiers in pharmacology · 2024Article
- Changes in Iron Status Biomarkers with Advancing Age According to Sex and Menopause: A Population-Based Study.Journal of clinical medicine · 2023Article
- The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings.Biomolecules · 2023Review
- Association of Early Hysterectomy With Risk of Cardiovascular Disease in Korean Women.JAMA network open · 2023Article
- Vascular Aging and Damage in Patients with Iron Metabolism Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.International journal of molecular sciences · 2022Article
- Serum calcium is a novel parameter to assess metabolic syndrome in endometrial carcinoma.Journal of gynecologic oncology · 2019Article
- Clinical factors affecting salivary transferrin level, a marker of blood contamination in salivary analysis.BMC oral health · 2018Article
- Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients.Integrative cancer therapies · 2017Article
- The Unexplored Crossroads of the Female Athlete Triad and Iron Deficiency: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2017Review
- Non-invasive Markers of Liver Fibrosis: Adjuncts or Alternatives to Liver Biopsy?Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesNo longitudinal studies have examined how iron measures change over menopause. Our objectives were to examine iron measures in individual women at premenopause and at postmenopause and, secondarily, to determine if any changes contributed to insulin resistance.
methodsIn a subset of participants (n=70) in a longitudinal study of menopause, we measured ferritin, transferrin, and soluble transferrin receptor (sTfR) once in the premenopause and once in the postmenopause. We also examined associations between menopausal status and change in iron markers after adjustment for age at menopause, race/ethnicity, and waist circumference. In linear regression models, we examined associations between premenopause iron measures and changes in iron markers over menopause with homeostasis model assessment of insulin resistance (HOMA-IR) changes over menopause, before and after adjustment for age at menopause, race/ethnicity, changes in waist circumference, C-reactive protein (CRP), and sex hormone-binding globulin (SHBG) levels.
resultsWomen had lower ferritin (p<0.01), higher sTfR:ferritin levels (p<0.01), lower HOMA-IR (p=0.022), and lower glucose (p=0.05) in premenopause compared to postmenopause. After adjustment, lower premenopausal iron levels (sTfR:ferritin levels β=11.0, 95% confidence interval [CI] 0.017-22.0) and larger increases in iron over menopause (changes in sTfR:ferritin β=13.6, 95% CI 0.93-26.3) were associated with larger increases in HOMA-IR.
conclusionsFrom premenopause to postmenopause, women on average have increases in measures of iron stores. Women who had the greatest changes in iron over menopause (lower measures of premenopausal iron and greater increases in iron measures over the menopause) had the strongest associations between changes in iron and changes in insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.