ArticleJournal of the American Chemical Society2012
3-Helix micelles stabilized by polymer springs.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Molecular Simulations of PEGylated Biomolecules, Liposomes, and Nanoparticles for Drug Delivery Applications.Pharmaceutics · 2020Review
- Multicomponent peptide assemblies.Chemical Society reviews · 2018Review
- Supramolecular aptamer nano-constructs for receptor-mediated targeting and light-triggered release of chemotherapeutics into cancer cells.Nature communications · 2018Article
- Fabrication of self-assembling nanofibers with optimal cell uptake and therapeutic delivery efficacy.Bioactive materials · 2017Article
- Understanding Peptide Oligomeric State in Langmuir Monolayers of Amphiphilic 3-Helix Bundle-Forming Peptide-PEG Conjugates.Biomacromolecules · 2016Article
- Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Controlling lipid micelle stability using oligonucleotide headgroups.Journal of the American Chemical Society · 2015Article
- Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity.Chemical communications (Cambridge, England) · 2015Article
- Environment-dependent guest exchange in supramolecular hosts.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Effect of alkyl length of peptide-polymer amphiphile on cargo encapsulation stability and pharmacokinetics of 3-helix micelles.Biomacromolecules · 2014Article
- Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer.Polymer chemistry · 2014Article
- Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.Frontiers in neuroanatomy · 2014Article
- Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers.Biomacromolecules · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Despite increasing demands to employ amphiphilic micelles as nanocarriers and nanoreactors, it remains a significant challenge to simultaneously reduce the particle size and enhance the particle stability. Complementary to covalent chemical bonding and attractive intermolecular interactions, entropic repulsion can be incorporated by rational design in the headgroup of an amphiphile to generate small micelles with enhanced stability. A new family of amphiphilic peptide-polymer conjugates is presented where the hydrophilic headgroup is composed of a 3-helix coiled coil with poly(ethylene glycol) attached to the exterior of the helix bundle. When micelles form, the PEG chains are confined in close proximity and are compressed to act as a spring to generate lateral pressure. The formation of 3-helix bundles determines the location and the directionalities of the force vector of each PEG elastic spring so as to slow down amphiphile desorption. Since each component of the amphiphile can be readily tailored, these micelles provide numerous opportunities to meet current demands for organic nanocarriers with tunable stability in life science and energy science. Furthermore, present studies open new avenues to use energy arising from entropic polymer chain deformation to self-assemble energetically stable, single nanoscopic objects, much like repulsion that stabilizes bulk assemblies of colloidal particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.