ArticleJournal of leukocyte biology2012
Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation.
Article in Journal of leukocyte biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Impact of cytomegalovirus load on host response to sepsis.Medical microbiology and immunology · 2019Review
- Impaired polyfunctionality of CD8Experimental & molecular medicine · 2017Article
- Broncholaveolar lavage to detect cytomegalovirus infection, latency, and reactivation in immune competent hosts.Journal of medical virology · 2016Article
- Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome.Intensive care medicine · 2016Article
- Article
- Sepsis and cytomegalovirus: foes or conspirators?Medical microbiology and immunology · 2015Review
- Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection.The Journal of experimental medicine · 2014Article
- Resistant pathogens, fungi, and viruses.The Surgical clinics of North America · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
It is clear that latent CMV can reactivate in immunocompetent individuals, but the mechanism triggering such reactivations remains unclear. Recent clinical data suggest that reactivation can be subverted by CMV-specific T-memory. We therefore monitored CMV-specific T cells in immunocompetent mice with latent mCMV after a known reactivation trigger (LPS). LPS induced transient systemic contraction of mCMV-specific CD8 memory that was followed by transcriptional reactivation. Subsequent recovery of mCMV-specific T cells coincided with resumption of latency. These data suggest that bacterial antigen encounters can induce transient T-memory contraction, allowing viral recrudescence in hosts latently infected with herpes family viruses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.