ArticleThe Plant cell2012
Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Induced and natural variation affect traits independently in hybrid Populus.G3 (Bethesda, Md.) · 2024Article
- Genetic Mapping of Genotype-by-Ploidy Effects inGenes · 2023Article
- Higher-order epistasis shapes natural variation in germ stem cell niche activity.Nature communications · 2023Article
- Functional Divergence Analysis ofPlants (Basel, Switzerland) · 2022Article
- The Role of Transcription Factors in the Regulation of Plant Shoot Branching.Plants (Basel, Switzerland) · 2022Review
- Potential transceptor AtNRT1.13 modulates shoot architecture and flowering time in a nitrate-dependent manner.The Plant cell · 2021Article
- Article
- Divergent Functional Diversification Patterns in the SEP/AGL6/AP1 MADS-Box Transcription Factor Superclade.The Plant cell · 2019Article
- Spatiotemporal control of axillary meristem formation by interacting transcriptional regulators.Development (Cambridge, England) · 2018Article
- Metabolite Profiles of Sugarcane Culm Reveal the Relationship Among Metabolism and Axillary Bud Outgrowth in Genetically Related Sugarcane Commercial Cultivars.Frontiers in plant science · 2018Article
- Tomato facultative parthenocarpy results from SlAGAMOUS-LIKE 6 loss of function.Plant biotechnology journal · 2017Article
- Prevalent Exon-Intron Structural Changes in the APETALA1/FRUITFULL, SEPALLATA, AGAMOUS-LIKE6, and FLOWERING LOCUS C MADS-Box Gene Subfamilies Provide New Insights into Their Evolution.Frontiers in plant science · 2016Article
- Article
- Protein change in plant evolution: tracing one thread connecting molecular and phenotypic diversity.Frontiers in plant science · 2013Review
- Acceleration of flowering in Arabidopsis thaliana by Cape Verde Islands alleles of FLOWERING H is dependent on the floral promoter FD.Journal of experimental botany · 2013Article
- Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution.Trends in genetics : TIG · 2013Review
- The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic background.PLoS genetics · 2013Article
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5 authors.
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Abstract
In the Arabidopsis multiparent recombinant inbred line mapping population, a limited number of plants were detected that lacked axillary buds in most of the axils of the cauline (stem) leaves, but formed such buds in almost all rosette axils. Genetic analysis showed that polymorphisms in at least three loci together constitute this phenotype, which only occurs in late-flowering plants. Early flowering is epistatic to two of these loci, called REDUCED SHOOT BRANCHING1 (RSB1) and RSB2, which themselves do not affect flowering time. Map-based cloning and confirmation by transformation with genes from the region where RSB1 was identified by fine-mapping showed that a specific allele of AGAMOUS-Like6 from accession C24 conferred reduced branching in the cauline leaves. Site-directed mutagenesis in the Columbia allele revealed the causal amino acid substitution, which behaved as dominant negative, as was concluded from a loss-of-function mutation that showed the same phenotype in the late-flowering genetic background. This causal allele occurs at a frequency of 15% in the resequenced Arabidopsis thaliana accessions and correlated with reduced stem branching only in late-flowering accessions. The data show the importance of natural variation and epistatic interactions in revealing gene function.
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