Evidence map›Paper›PMID 22730388›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2012

Vascular effects of maternal alcohol consumption.

Jayanth Ramadoss, Ronald R Magness

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption.Alcoholism, clinical and experimental research · 2018
    Review
  17. Article
  18. Fetal regional brain protein signature in FASD rat model.Reproductive toxicology (Elmsford, N.Y.) · 2018
    Article
  19. Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jayanth RamadossDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA. jaramado@utmb.edu
Ronald R Magness
The University of Texas Medical Branch at Galveston · USUniversity of Wisconsin–Madison · US

Funding

Unified Cellular and Molecular CoreP01HD038843 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN · 2001 to 2017
$14.4M
ENDOTHELIUM-DERIVED VASODILATORS IN PREGNANCYR01HL049210 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MAGNESS, RONALD R · 1993 to 2011
$2.6M
Maternal Uterine Vascular Origins of Fetal Alcohol Spectrum DisordersR00AA019446 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI RAMADOSS, JAYANTH · 2011 to 2013
$730k
Maternal Uterine Vascular Origins of Fetal Alcohol Spectrum DisordersK99AA019446 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI RAMADOSS, JAYANTH · 2010 to 2011
$267k
NHLBI NIH HHS HL-49210NHLBI NIH HHS HL-89144NIAAA NIH HHS AA-19446NIAAA NIH HHS R00 AA019446NICHD NIH HHS HD-38843
6 · The paper itself

Abstract

Maternal alcohol consumption during pregnancy is a significant field of scientific exploration primarily because of its negative effects on the developing fetus, which is specifically defined as fetal alcohol spectrum disorders. Though the effects on the mother are less explored compared with those on the fetus, alcohol produces multiple effects on the maternal vascular system. Alcohol has major effects on systemic hemodynamic variables, endocrine axes, and paracrine factors regulating vascular resistance, as well as vascular reactivity. Alcohol is also reported to have significant effects on the reproductive vasculature including alterations in blood flow, vessel remodeling, and angiogenesis. Data presented in this review will illustrate the importance of the maternal vasculature in the pathogenesis of fetal alcohol spectrum disorders and that more studies are warranted in this field.

Indexed as

Alcohol DrinkingAnimalsAutonomic Nervous SystemBlood VesselsEthanolFemaleFetal Alcohol Spectrum DisordersHemodynamicsHumansHypothalamo-Hypophyseal SystemParacrine CommunicationPlacental CirculationPregnancySignal TransductionEthanol

Identifiers

PMID22730388
PMCPMC3423142
OpenAlexW2122404985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.