ReviewEndocrine2012
Testosterone and heart failure.
Review in Endocrine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial.European journal of nutrition · 2019Trial
- Testosterone deficiency independently predicts mortality in women with HFrEF: insights from the T.O.S.CA. registry.ESC heart failure · 2023Observational
- Effects of Concurrent, Within-Session, Aerobic and Resistance Exercise Training on Functional Capacity and Muscle Performance in Elderly Male Patients with Chronic Heart Failure.Journal of clinical medicine · 2023Article
- Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training.Frontiers in physiology · 2023Review
- Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure.Frontiers in molecular biosciences · 2021Review
- Review
- Heart Failure-Induced Skeletal Muscle Wasting.Current heart failure reports · 2020Review
- Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity.International journal of endocrinology · 2020Article
- Pharmacological management of cardiac cachexia: a review of potential therapy options.Heart failure reviews · 2019Review
- Testosterone and the Heart.European cardiology · 2019Review
- A 3-year observation of testosterone deficiency in Chinese patients with chronic heart failure.Oncotarget · 2017Article
- Review
- Central and peripheral testosterone effects in men with heart failure: An approach for cardiovascular research.World journal of cardiology · 2015Article
- Testosterone deficiency, insulin-resistant obesity and cognitive function.Metabolic brain disease · 2015Review
- Natural course of hypogonadism diagnosed during hospitalization in aged male patients.Endocrine · 2015Article
- GH and the cardiovascular system: an update on a topic at heart.Endocrine · 2015Review
- Effects of testosterone undecanoate replacement and withdrawal on cardio-metabolic, hormonal and body composition outcomes in severely obese hypogonadal men: a pilot study.Journal of endocrinological investigation · 2014Article
- Cachexia in chronic heart failure: endocrine determinants and treatment perspectives.Endocrine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone deficiency is a generalized phenomenon seen in the course of chronic heart failure (CHF). Reduction in circulating testosterone level is a predictor of deterioration of functional capacity over time, underscoring the role of testosterone deficiency in CHF. Anabolic hormones are determinants of exercise capacity and circulating levels of anabolic hormones strongly determine muscle mass and strength. Testosterone deficiency is involved in the pathophysiology of CHF, contributing to some features of this syndrome, such as the reduced muscle mass, abnormal energy handling, fatigue, dyspnea and, finally, cachexia. This review summarizes current knowledge on the role of testosterone deficiency in the pathophysiology of CHF, gaining insights from the potential implications of testosterone as supplementation therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.