ArticleMolecular biology reports2012
Polymorphism of insulin-like growth factor 1 gene and its association with litter size in Small Tail Han sheep.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Genotypic and expression analysis of the insulin- like growth factor (IGF-1) gene across growth stages in indigenous sheep.Molecular biology reports · 2026Article
- Genomic structures of insulin-like growth factor from golden pompano (Trachinotus ovatus) and their expression responses to the feed types.Fish physiology and biochemistry · 2024Article
- Genome-wide comparative analysis reveals selection signatures for reproduction traits in prolific Suffolk sheep.Frontiers in genetics · 2024Article
- Association of theVeterinary sciences · 2023Article
- Characterization of polymorphisms in the follicle-stimulating hormone receptor and insulin-like growth factor-1 genes and their association with fertility traits in Jawa-Brebes cows.Veterinary world · 2023Article
- Genetic Polymorphisms ofGenes · 2022Article
- A Novel SNP in the Promoter Region ofFrontiers in cell and developmental biology · 2022Article
- Article
- Nucleotide Sequence Variation in the Insulin-Like Growth Factor 1 Gene Affects Growth and Carcass Traits in New Zealand Romney Sheep.DNA and cell biology · 2021Article
- Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep.Veterinary and animal science · 2020Article
- Article
- cDNA cloning, structural analysis, SNP detection and tissue expression profile of the IGF1 gene in Malabari and Attappady Black goats of India.Journal of genetics · 2017Article
- Polymorphism of Prophet of Pit-1 gene and its relationship with litter size of Small Tail Han sheep.Journal of genetics · 2015Article
- Cloning and characterization of a ribosomal protein L23a gene from Small Tail Han sheep by screening of a cDNA expression library.Meta gene · 2014Article
- Study on characteristics of chemokine CXCL10 gene cloned from cDNA expression library of Ujumqin sheep.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulin-like growth factor 1 (IGF1) gene was studied as a candidate gene for high prolificacy in sheep. Polymorphisms of 5' regulatory region and all four exons of IGF1 gene were detected in Small Tail Han (n = 277), Hu (n = 58), Texel (n = 48) and Dorset (n = 46) sheep by PCR-RFLP and PCR-SSCP analysis. A microsatellite polymorphic site and a restriction fragment length polymorphism were shown in the 5' regulatory region of IGF1 gene. The ewes with genotype 123/123 bp had 0.81 (P < 0.05) or 1.03 (P < 0.01) lambs more than those with genotype 125/125 bp or 125/127 bp, the ewes with genotype 123/125 bp had 0.46 (P < 0.05) or 0.68 (P < 0.01) lambs more than those with genotype 125/125 bp or 125/127 bp. In addition, there were two mutations (C1511G and A1513G) in 5' regulatory region of IGF1 gene. The ewes with genotype BB or AB had 0.96 (P < 0.05) or 0.38 (P < 0.05) lambs more than those with genotype AA, but there were no significant differences between BB and AB genotypes (P > 0.05) in Small Tail Han sheep. These results preliminarily indicated that these polymorphisms of IGF1 gene could be used in molecular marker-assisted selection for sheep breeding programs.
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