ReviewPflugers Archiv : European journal of physiology2013
Metabolic control of renin secretion.
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Sensing succinate: SUCNR1 as a context-dependent metabolic and cellular signal integrator.Frontiers in molecular biosciences · 2026Review
- Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism.The FEBS journal · 2025Article
- Research progress on intratumoral microorganisms in renal cancer.World journal of urology · 2025Review
- High Salt Remodels Kidney Metabolism: Metabolite Fuel, Fate, and Signals.Function (Oxford, England) · 2024Article
- Preliminary Exploration of Metabolic Mechanisms in Copper-ExposedMetabolites · 2023Article
- Divulging a Pleiotropic Role of Succinate ReceptorCancers · 2022Article
- α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and NaFrontiers in cardiovascular medicine · 2021Article
- Pulmonary Pathogens Adapt to Immune Signaling Metabolites in the Airway.Frontiers in immunology · 2020Review
- SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.Nature immunology · 2019Article
- Identification and pharmacological characterization of succinate receptor agonists.British journal of pharmacology · 2017Article
- Increased urinary prostaglandin E2 metabolite: A potential therapeutic target of Gitelman syndrome.PloS one · 2017Article
- Regulation of Vascular and Renal Function by Metabolite Receptors.Annual review of physiology · 2016Review
- Salt-Sensitive Hypertension: Perspectives on Intrarenal Mechanisms.Current hypertension reviews · 2015Review
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats.American journal of physiology. Renal physiology · 2014Article
- Intrarenal renin-angiotensin system in regulation of glomerular function.Current opinion in nephrology and hypertension · 2014Review
- Renal and cardiovascular sensory receptors and blood pressure regulation.American journal of physiology. Renal physiology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
One emerging topic in renin-angiotensin system (RAS) research is the direct local control of renin synthesis and release by endogenous metabolic intermediates. During the past few years, our laboratory has characterized the localization and signaling of the novel metabolic receptor GPR91 in the normal and diabetic kidney and established GPR91 as a new, direct link between high glucose and RAS activation in diabetes. GPR91 (also called SUCNR1) binds tricarboxylic acid (TCA) cycle intermediate succinate which can rapidly accumulate in the local tissue environment when energy supply and demand are out of balance. In a variety of physiological and pathological conditions associated with metabolic stress, succinate signaling via GPR91 appears to be an important mediator or modulator of renin secretion. This review summarizes our current knowledge on the control of renin release by molecules of endogenous metabolic pathways with the main focus on succinate/GPR91.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.