ArticleJournal of pharmacokinetics and pharmacodynamics2012
General relationship between transit compartments and lifespan models.
Article in Journal of pharmacokinetics and pharmacodynamics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Delay differential equations based models in NONMEM.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Lifespan based pharmacokinetic-pharmacodynamic model of tumor growth inhibition by anticancer therapeutics.PloS one · 2014Article
- Solution and implementation of distributed lifespan models.Journal of pharmacokinetics and pharmacodynamics · 2013Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transit compartment models (TCM) are important tools in pharmacokinetic/pharmacodynamic (PKPD) modeling. In this work we investigate the relationship between TCMs with arbitrary initial values and lifespan models (LSM) with non-constant past and constant lifespan. We show that the total population in all transit compartments converges to a LSM, if the number of compartments n tends to infinity. The key to obtain this result is to establish a relationship between the initial values of the TCM and the non-constant past of the LSM. We apply the result to two already published PKPD models.
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