ArticleMedical & biological engineering & computing2012
Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential.
Article in Medical & biological engineering & computing, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study.PLoS computational biology · 2018Article
- The roles of mid-myocardial and epicardial cells in T-wave alternans development: a simulation study.Biomedical engineering online · 2018Article
- Modeling dynamics in diseased cardiac tissue: Impact of model choice.Chaos (Woodbury, N.Y.) · 2017Article
- Improved robust T-wave alternans detectors.Medical & biological engineering & computing · 2015Article
- Dynamics of propagation of premature impulses in structurally remodeled infarcted myocardium: a computational analysis.Frontiers in physiology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac arrhythmias are initiated in regions that undergo cellular remodeling as a result of disease. Using a sub-cellular model of myocardium, we studied the mechanism of block caused by tissue microstructure remodeling: cell geometry [quantified as length/width (L/W) cell ratio] and cell-to-cell coupling (G(j)). Heterogeneities in cell L/W ratio and G ( j ) lead to block when excitability is reduced and the corresponding space constant λ (in the direction of propagation) increases by >40 %. Tissue architectures with elongated cells (i.e. large cell L/W ratios) that are better coupled (i.e. large G(j)) are less prone to block at sites of regional heterogeneities in cell geometry and/or cell coupling than tissue architectures consisting of cells with smaller L/W ratios and/or poorer coupling. Whether an increase in tissue anisotropic ratio (ANR) is arrhythmogenic or not depends on the cellular mechanism of the increase: ANR leads to an increased risk of block when G(j) decreases, but to a decreased risk of block when cell L/W ratio increases. Our findings are useful to understand the mechanisms of block in cardiac pathologies that result in tissue architecture remodeling.
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Registered trials
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