ArticleLab on a chip2012
DNA circuits as amplifiers for the detection of nucleic acids on a paperfluidic platform.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A geometric framework for reaction enumeration in computational nucleic acid devices.Journal of the Royal Society, Interface · 2023Article
- Addition of mirror-image L-DNA elements to DNA amplification circuits to distinguish leakage from target signal.Biosensors & bioelectronics · 2021Article
- Article
- Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices.Molecules (Basel, Switzerland) · 2019Review
- Simultaneous Detection of Different Zika Virus Lineages via Molecular Computation in a Point-of-Care Assay.Viruses · 2018Article
- Direct nucleic acid analysis of mosquitoes for high fidelity species identification and detection of Wolbachia using a cellphone.PLoS neglected tropical diseases · 2018Article
- Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases.BioImpacts : BI · 2018Article
- A Microsphere-Supported Lipid Bilayer Platform for DNA Reactions on a Fluid Surface.ACS applied materials & interfaces · 2017Article
- Biomimetic Molecular Signaling using DNA Walkers on Microparticles.Scientific reports · 2017Article
- Purification of single-stranded DNA by co-polymerization with acrylamide and electrophoresis.BioTechniques · 2017Article
- Kinetics of DNA Strand Displacement Systems with Locked Nucleic Acids.The journal of physical chemistry. B · 2017Article
- A Spinach molecular beacon triggered by strand displacement.RNA (New York, N.Y.) · 2014Article
- Signal propagation in multi-layer DNAzyme cascades using structured chimeric substrates.Angewandte Chemie (International ed. in English) · 2014Article
- Diagnostic applications of nucleic acid circuits.Accounts of chemical research · 2014Article
- Design and application of cotranscriptional non-enzymatic RNA circuits and signal transducers.Nucleic acids research · 2014Article
- DNA detection using origami paper analytical devices.Analytical chemistry · 2013Article
- Chemical analog-to-digital signal conversion based on robust threshold chemistry and its evaluation in the context of microfluidics-based quantitative assays.Journal of the American Chemical Society · 2013Article
- Recent advances in paper-based sensors.Sensors (Basel, Switzerland) · 2012Review
- Open source and DIY hardware for DNA nanotechnology labs.Journal of biological methodsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This article describes the use of non-enzymatic nucleic acid circuits based on strand exchange reactions to detect target sequences on a paperfluidic platform. The DNA circuits that were implemented include a non-enzymatic amplifier and transduction to a fluorescent reporter; these yield an order of magnitude improvement in detection of an input nucleic acid signal. To further improve signal amplification and detection, we integrated the enzyme-free amplifier with loop-mediated isothermal amplification (LAMP). By bridging the gap between the low concentrations of LAMP amplicons and the limits of fluorescence detection, the non-enzymatic amplifier allowed us to detect as few as 1200 input templates in a paperfluidic format.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.