ArticleVirus research2012
Mycophenolate mofetil inhibits hepatitis C virus replication in human hepatic cells.
Article in Virus research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus.International journal of molecular sciences · 2022Article
- Screening and identification of HTNVVirologica Sinica · 2022Article
- Drug repurposing approach to combating coronavirus: Potential drugs and drug targets.Medicinal research reviews · 2021Review
- Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery.Frontiers in pharmacology · 2021Review
- Suppression of autophagy by mycophenolic acid contributes to inhibition of HCV replication in human hepatoma cells.Scientific reports · 2017Article
- Effects of Phenylglyoxal and N-ethylmaleimide Concentration on Mycophenolic Acid Production byIranian journal of pharmaceutical research : IJPR · 2016Article
- Post-transplantation malignancies: here today, gone tomorrow?Nature reviews. Clinical oncology · 2015Review
- Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector.Virology · 2015Article
- Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.Virus research · 2014Review
- Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease.Acta pharmacologica Sinica · 2014Article
- Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.The Journal of infection · 2013Article
- Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis.PloS one · 2013Article
- Should we consider patients with coexistent hepatitis B or C infection for orthotopic heart transplantation?Journal of transplantation · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Hepatitis C virus (HCV) infection is the most common indication for liver transplantation and the major cause of graft failure. A widely used immunosuppressant, cyclosporine A (CsA), for people who receive organ transplantation, has been recognized to have the ability to inhibit HCV replication both in vivo and in vitro. In this study, we investigated the effects of several other immunosuppressants, including mycophenolate mofetil (MMF), rapamycin and FK506, on HCV replication in human hepatic cells. MMF treatment of hepatic cells before or during HCV infection significantly suppressed full cycle viral replication, as evidenced by decreased expression of HCV RNA, protein and production of infectious virus. In contrast, rapamycin and FK506 had little effect on HCV replication. Investigation of the mechanism(s) disclosed that the inhibition of HCV replication by MMF was mainly due to its depletion of guanosine, a purine nucleoside crucial for synthesis of guanosine triphosphate, which is required for HCV RNA replication. The supplement of exogenous guanosine could reverse most of anti-HCV effect of mycophenolate mofetil. These data indicate that MMF, through the depletion of guanosine, inhibits full cycle HCV JFH-1 replication in human hepatic cells. It is of interest to further determine whether MMF is indeed beneficial for HCV-infected transplant recipients in future clinical studies.
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Registered trials
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