Trial reportJournal of acquired immune deficiency syndromes (1999)2012
The effect of anthelmintic treatment during pregnancy on HIV plasma viral load: results from a randomized, double-blind, placebo-controlled trial in Uganda.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy.The Cochrane database of systematic reviews · 2021Pooled it
- Maternal Hookworm Infection and Its Effects on Maternal Health: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2020Pooled it
- Antihelminthics in helminth-endemic areas: effects on HIV disease progression.The Cochrane database of systematic reviews · 2016Pooled it
- Cohort profile: the Entebbe Mother and Baby Study (EMaBS).BMJ open · 2026Trial
- Determinants of Gammaherpesvirus Shedding in Saliva Among Ugandan Children and Their Mothers.The Journal of infectious diseases · 2018Trial
- Can combination prevention strategies reduce HIV transmission in generalized epidemic settings in Africa? The HPTN 071 (PopART) study plan in South Africa and Zambia.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- The Impact of Pulmonary Hydatid Cyst Rupture on COVID-19 Symptom Severity.Acta parasitologica · 2024Article
- Mass deworming for soil-transmitted helminths and schistosomiasis among pregnant women: A systematic review and individual participant data meta-analysis.Campbell systematic reviews · 2019Review
- Effect of high-intensity versus low-intensity praziquantel treatment on HIV disease progression in HIV andWellcome open research · 2018Article
- Tropical Parasitic Infections in Individuals Infected with HIV.Current tropical medicine reports · 2017Article
- Hookworm infection is associated with decreased CD4+ T cell counts in HIV-infected adult Ugandans.PLoS neglected tropical diseases · 2017Article
- Helminth infection during pregnancy: insights from evolutionary ecology.International journal of women's health · 2016Review
- Treatment of W. bancrofti (Wb) in HIV/Wb coinfections in South India.PLoS neglected tropical diseases · 2015Article
- Are pregnant women with chronic helminth infections more susceptible to congenital infections?Frontiers in immunology · 2014Review
- Water, sanitation, hygiene and enteric infections in children.Archives of disease in childhood · 2013Article
- Factors affecting the infant antibody response to measles immunisation in Entebbe-Uganda.BMC public health · 2013Article
- Exploring gender dimensions of treatment programmes for neglected tropical diseases in Uganda.PLoS neglected tropical diseases · 2013Article
- Helminth infection in populations undergoing epidemiological transition: a friend or foe?Seminars in immunopathology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTo investigate the effect of helminth infections and their treatment during pregnancy on HIV load, we conducted a 2 × 2 factorial randomized controlled trial of albendazole versus placebo and praziquantel versus placebo in pregnant women in Entebbe, Uganda.
methodsTwo hundred sixty-four HIV-infected pregnant women from the Entebbe Mother and Baby Study (ISRCTN 32849447) were included in this analysis. Women were tested for helminth infections at enrollment, and mean HIV load was compared between infected and uninfected groups. The effect of anthelmintic treatment on HIV load was evaluated at 6 weeks after treatment and at delivery using linear regression and adjusting for enrollment viral load.
resultsHookworm and Trichuris infections were associated with higher mean viral load at enrollment [adjusted mean difference 0.24 log10 copies/mL, 95% confidence interval (CI): 0.01 to 0.47, P = 0.03, and 0.37 log(10) copies/mL, 95% CI: 0.00 to 0.74, P = 0.05, respectively]. There were no associations between viral load and other helminth species. There was some evidence that albendazole reduced viral load at 6 weeks after treatment (adjusted mean difference -0.17, 95% CI: -0.36 to 0.01, P = 0.07); however, this effect did not differ according to mother's hookworm infection status and had diminished at delivery (adjusted mean difference -0.11, 95% CI: -0.28 to 0.07, P = 0.23). There was no effect of praziquantel treatment on HIV load at any time point.
conclusionsInfection with some soil-transmitted helminth species is associated with increased HIV load in pregnancy. Treatment with albendazole causes a small decrease in HIV load; however, this may not represent a direct effect of worm removal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.