ReviewSeminars in cell & developmental biology2012
Crosstalk between the developing pancreas and its blood vessels: an evolving dialog.
Review in Seminars in cell & developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Islet ultrastructure: past achievements and future directions.Diabetologia · 2026Review
- Unravelling the developmental origins of cystic fibrosis-related diabetes.Diabetologia · 2026Review
- Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas.Scientific reports · 2024Article
- Identification and implication of tissue-enriched ligands in epithelial-endothelial crosstalk during pancreas development.Scientific reports · 2022Article
- Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas.Diabetes · 2020Article
- Cell-Cell Communication Breakdown and Endothelial Dysfunction.Critical care clinics · 2020Review
- Exploring the Molecular Crosstalk between Pancreatic Bud and Mesenchyme in Embryogenesis: Novel Signals Involved.International journal of molecular sciences · 2019Article
- (Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives.Physiological reviews · 2018Review
- Human Organ-Specific Endothelial Cell Heterogeneity.iScience · 2018Article
- Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry.Journal of visualized experiments : JoVE · 2017Article
- Vascular development in the vertebrate pancreas.Developmental biology · 2016Article
- Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche.Genes & development · 2015Article
- Pancreatic islet cell development and regeneration.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Endothelial cells mediate islet-specific maturation of human embryonic stem cell-derived pancreatic progenitor cells.Tissue engineering. Part A · 2015Article
- Identification, evolution and expression of an insulin-like peptide in the cephalochordate Branchiostoma lanceolatum.PloS one · 2015Article
- Molecular pathways: not a simple tube--the many functions of blood vessels.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Review
- Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice.Diabetologia · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Growth and development of embryonic organs goes hand in hand with development of the vascular system. Blood vessels have been known for centuries to supply nutrients and oxygen to all cell types in an organism, however, they have more recently been shown to provide specific cues required for the formation and functionality of a number of tissues. Here, we review the role of blood vessels during pancreas formation, from early specification of the initial pancreatic bud, to its growth and maturation. The overarching theme that emerges from the many studies carried out in the past decade is that the vasculature likely plays diverse and changing roles during pancreas organogenesis. Blood vessels are required for endocrine specification at the onset of pancreatic budding, while only a few days later, blood vessels suppress pancreatic branching and exocrine differentiation. In this review, we summarize our understanding to date about the crosstalk between the pancreas and its vasculature, and we provide a perspective on the promises and challenges of the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.