Evidence map›Paper›PMID 22728166›Full record

Trial reportTranslational research : the journal of laboratory and clinical medicine2013

Antioxidant supplementation reduces endometriosis-related pelvic pain in humans.

Nalini Santanam, Nino Kavtaradze, Ana Murphy, Celia Dominguez, Sampath Parthasarathy

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational research : the journal of laboratory and clinical medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 8 pooled it
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 8 syntheses or guidelines pooled it, 171 citations in OpenAlex.

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  8. Dietary supplements for dysmenorrhoea.The Cochrane database of systematic reviews · 2016
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nalini SantanamDepartment of Pharmacology, Physiology, and Toxicology, Joan C. Edwards School of Medicine, Huntington, West Virginia.
Nino Kavtaradze
Ana Murphy
Celia Dominguez
Sampath Parthasarathy
Augusta University · USEmory University · USMarshall University · USUniversity of Central Florida · US

Funding

ROLE OF CSF1 AND ITS RECEPTOR IN ENDOMETRIOSISP01HD035276 · NICHD · EMORY UNIVERSITY · PI MURPHY, ANA ALVAREZ · 1999 to 2003
$3.1M
NICHD NIH HHS P01 HD035276NICHD NIH HHS P01-HD-35276-01A1
6 · The paper itself

Abstract

We previously suggested that women with endometriosis have increased oxidative stress in the peritoneal cavity. To assess whether antioxidant supplementation would ameliorate endometriosis-associated symptoms, we performed a randomized, placebo-controlled trial of antioxidant vitamins (vitamins E and C) in women with pelvic pain and endometriosis. Fifty-nine women, ages 19 to 41 years, with pelvic pain and history of endometriosis or infertility were recruited for this study. Patients were randomly assigned to 2 groups: vitamin E (1200 IU) and vitamin C (1000 mg) combination or placebo daily for 8 weeks before surgery. Pain scales were administered at baseline and biweekly. Inflammatory markers were measured in the peritoneal fluid obtained from both groups of patients at the end of therapy. Our results indicated that after treatment with antioxidants, chronic pain ("everyday pain") improved in 43% of patients in the antioxidant treatment group (P = 0.0055) compared with the placebo group. In the same group, dysmenorrhea ("pain associated with menstruation") and dyspareunia ("pain with sex") decreased in 37% and 24% patients, respectively. In the placebo group, dysmenorrhea-associated pain decreased in 4 patients and no change was seen in chronic pain or dyspareunia. There was a significant decrease in peritoneal fluid inflammatory markers, regulated upon activation, normal T-cell expressed and secreted (P ≤ 0.002), interleukin-6 (P ≤ 0.056), and monocyte chemotactic protein-1 (P ≤ 0.016) after antioxidant therapy compared with patients not taking antioxidants. The results of this clinical trial show that administration of antioxidants reduces chronic pelvic pain in women with endometriosis and inflammatory markers in the peritoneal fluid.

Indexed as

AdultAntioxidantsAscitic FluidAscorbic AcidChemokine CCL2Chemokine CCL5DysmenorrheaDyspareuniaEndometriosisFemaleHumansInflammation MediatorsInterleukin-6Oxidative StressPain MeasurementPelvic PainAntioxidantsAscorbic AcidCCL2 protein, humanCCL5 protein, humanChemokine CCL2Chemokine CCL5IL6 protein, humanInflammation MediatorsInterleukin-6Vitamin E

Identifiers

PMID22728166
PMCPMC3484190
OpenAlexW1969421128

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.