Evidence map›Paper›PMID 22728063›Full record

ReviewCurrent opinion in cell biology2012

Structures and mechanisms of vesicle coat components and multisubunit tethering complexes.

Lauren P Jackson, Daniel Kümmel, Karin M Reinisch, David J Owen

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  3. Article
  4. Review
  5. Cryo-EM structure of the exocyst complex.Nature structural & molecular biology · 2018
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lauren P JacksonCambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, UK. lpj21@cam.ac.uk
Daniel Kümmel
Karin M Reinisch
David J Owen

Funding

Regulatory Mechanisms in Membrane TraffickingR01GM080616 · NIGMS · YALE UNIVERSITY · PI REINISCH, KARIN M · 2007 to 2018
$4.1M
NIGMS NIH HHS GM080616NIGMS NIH HHS R01 GM080616Wellcome Trust 090909
6 · The paper itself

Abstract

Eukaryotic cells face a logistical challenge in ensuring prompt and precise delivery of vesicular cargo to specific organelles within the cell. Coat protein complexes select cargo and initiate vesicle formation, while multisubunit tethering complexes participate in the delivery of vesicles to target membranes. Understanding these macromolecular assemblies has greatly benefited from their structural characterization. Recent structural data highlight principles in coat recruitment and uncoating in both the endocytic and retrograde pathways, and studies on the architecture of tethering complexes provide a framework for how they might link vesicles to the respective acceptor compartments and the fusion machinery.

Indexed as

Adaptor Proteins, Vesicular TransportAuxilinsBiological TransportCoated VesiclesCOP-Coated VesiclesHumansProtein SubunitsAdaptor Proteins, Vesicular TransportAuxilinsProtein Subunits

Identifiers

PMID22728063
PMCPMC3425711

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.