ArticleNeurobiology of aging2013
Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapses.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Sex-specific frontal cortical circuit mechanisms mediating fear extinction.bioRxiv : the preprint server for biology · 2026Article
- Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation.Brain structure & function · 2025Article
- Preservation of cellular structure via immersion fixation in brain banking.Free neuropathology · 2025Article
- Structural plasticity of pyramidal cell neurons measured after FLASH and conventional dose-rate irradiation.Research square · 2024Article
- Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits.Aging cell · 2024Article
- Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs.Molecular autism · 2024Article
- The times they are a-changin': a proposal on how brain flexibility goes beyond the obvious to include the concepts of "upward" and "downward" to neuroplasticity.Molecular psychiatry · 2023Review
- Cognitive aging is associated with redistribution of synaptic weights in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats.Molecular autism · 2020Article
- Reduced sensory-evoked structural plasticity in the aging barrel cortex.Neurobiology of aging · 2019Article
- Network analysis of aging acceleration reveals systematic properties of 11 types of cancers.FEBS open bio · 2019Article
- Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Alterations in synaptic density and myelination in response to exposure to high-energy charged particles.The Journal of comparative neurology · 2018Article
- Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex.Frontiers in aging neuroscience · 2018Article
- GABAergic Networks in the Prefrontal Cortex and Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics between young and old mice.Scientific reports · 2017Article
- Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine.Current neuropharmacology · 2017Review
- NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.Molecular neurobiology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Age-related impairments of executive functions appear to be related to reductions of the number and plasticity of dendritic spine synapses in the prefrontal cortex (PFC). Experimental evidence suggests that synaptic plasticity is mediated by the spine actin cytoskeleton, and a major pathway regulating actin-based plasticity is controlled by phosphorylated LIM kinase (pLIMK). We asked whether aging resulted in altered synaptic density, morphology, and pLIMK expression in the rat prelimbic region of the PFC. Using unbiased electron microscopy, we found an approximate 50% decrease in the density of small synapses with aging, while the density of large synapses remained unchanged. Postembedding immunogold revealed that pLIMK localized predominantly to the postsynaptic density where it was increased in aging synapses by approximately 50%. Furthermore, the age-related increase in pLIMK occurred selectively within the largest subset of prelimbic PFC synapses. Because pLIMK is known to inhibit actin filament plasticity, these data support the hypothesis that age-related increases in pLIMK may explain the stability of large synapses at the expense of their plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.