ArticleBMC microbiology2012
Zinc-induced envelope stress diminishes type III secretion in enteropathogenic Escherichia coli.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Metals in the gut: microbial strategies to overcome nutritional immunity in the intestinal tract.Metallomics : integrated biometal science · 2024Review
- Antimicrobial effects in oral microenvironments by a novel herbal toothpaste.Contemporary clinical trials communications · 2021Article
- Critical Role of Zinc in a New Murine Model of Enterotoxigenic Escherichia coli Diarrhea.Infection and immunity · 2018Article
- Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota.Frontiers in microbiology · 2018Review
- Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli.PloS one · 2017Article
- Article
- Micronutrients: A Double-Edged Sword in Microbe-Induced Gastric Carcinogenesis.Trends in cancer · 2015Review
- The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence.Infection and immunity · 2015Article
- The RpoE Stress Response Pathway Mediates Reduction of the Virulence of Enteropathogenic Escherichia coli by Zinc.Applied and environmental microbiology · 2015Article
- From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli.Frontiers in microbiology · 2015Review
- Novel MntR-independent mechanism of manganese homeostasis in Escherichia coli by the ribosome-associated protein HflX.Journal of bacteriology · 2014Article
- Zinc protects against Shiga-toxigenic Escherichia coli by acting on host tissues as well as on bacteria.BMC microbiology · 2014Article
- Article
- From ambivalent to divalent: Has the "zinc age" finally arrived?Virulence · 2013Article
- The transcriptional regulator Np20 is the zinc uptake regulator in Pseudomonas aeruginosa.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDietary supplementation with zinc has been shown to reduce the duration and severity of diarrhoeal disease caused by Enteropathogenic Escherichia coli, common in infants in developing countries. Initially this therapeutic benefit was attributed to the correction of zinc deficiency in malnourished individuals, but recently evidence has emerged that zinc significantly impacts the pathogens themselves: zinc concentrations achievable by oral supplementation can reduce the expression of key virulence-related genes in EPEC and related organisms.
resultsHere, we investigate three possible mechanisms for such zinc-induced changes in expression of EPEC virulence: direct interaction of zinc with regulators of LEE operons; genetic interaction of LEE operons with known regulators of zinc homeostasis; and finally, downregulation of LEE transcription associated with activation of the σ(E) envelope stress response by zinc. We find evidence only for the latter mechanism, including zinc-induced down-regulation of type III secretion in EPEC similar to that caused by ammonium metavanadate, another known inducer of the σ(E) stress response.
conclusionsWe conclude therefore that envelope stress is a major mechanism by which zinc attenuates the virulence of EPEC and related pathogens.
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Registered trials
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