ArticleBMC genomics2012
Genome characterisation of the genus Francisella reveals insight into similar evolutionary paths in pathogens of mammals and fish.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Genomic Evolution of Francisella: Metabolic Innovation, Endosymbiotic Transitions to Ticks, and Biogeographic History.Genome biology and evolution · 2026Article
- A Structurally Divergent Class Ia Ribonucleotide Reductase from a Tick-Borne Pathogen.Biochemistry · 2025Article
- Identification of theFrontiers in cellular and infection microbiology · 2025Article
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- Host-bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts.FEMS microbiology reviews · 2024Review
- Mutation ofMicrobiology (Reading, England) · 2024Article
- Bipolar Biogeographical Distribution of Parafrancisella Bacteria Carried by the Ciliate Euplotes.Microbial ecology · 2023Article
- Decontamination protocols affect the internal microbiota of ticks.Parasites & vectors · 2023Article
- Identification ofMicroorganisms · 2023Article
- Comparative analysis of absent in melanoma 2-inflammasome activation inFrontiers in microbiology · 2023Article
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- Co-Occurrence ofMicroorganisms · 2022Article
- Ecological Contacts and Host Specificity Promote Replacement of Nutritional Endosymbionts in Ticks.Microbial ecology · 2022Article
- Why vary what's working? Phase variation and biofilm formation inFrontiers in microbiology · 2022Review
- Article
- Disruption of the Francisella noatunensis subsp.Infection and immunity · 2021Article
- Characterization of the bacterial microbiome of Rhipicephalus (Boophilus) microplus collected from Pecari tajacu "Sajino" Madre de Dios, Peru.Scientific reports · 2021Article
- Long-Term Survival of Virulent Tularemia Pathogens outside a Host in Conditions That Mimic Natural Aquatic Environments.Applied and environmental microbiology · 2021Article
- First Description of a Temperate Bacteriophage (vBViruses · 2021Article
- Tularemia: a re-emerging tick-borne infectious disease.Folia microbiologica · 2021Review
13 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrior to this study, relatively few strains of Francisella had been genome-sequenced. Previously published Francisella genome sequences were largely restricted to the zoonotic agent F. tularensis. Only limited data were available for other members of the Francisella genus, including F. philomiragia, an opportunistic pathogen of humans, F. noatunensis, a serious pathogen of farmed fish, and other less well described endosymbiotic species.
resultsWe determined the phylogenetic relationships of all known Francisella species, including some for which the phylogenetic positions were previously uncertain. The genus Francisella could be divided into two main genetic clades: one included F. tularensis, F. novicida, F. hispaniensis and Wolbachia persica, and another included F. philomiragia and F. noatunensis.Some Francisella species were found to have significant recombination frequencies. However, the fish pathogen F. noatunensis subsp. noatunensis was an exception due to it exhibiting a highly clonal population structure similar to the human pathogen F. tularensis.
conclusionsThe genus Francisella can be divided into two main genetic clades occupying both terrestrial and marine habitats. However, our analyses suggest that the ancestral Francisella species originated in a marine habitat. The observed genome to genome variation in gene content and IS elements of different species supports the view that similar evolutionary paths of host adaptation developed independently in F. tularensis (infecting mammals) and F. noatunensis subsp. noatunensis (infecting fish).
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