Evidence map›Paper›PMID 22726697›Full record

ReviewTrends in parasitology2012

Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival.

Norikiyo Ueno, Mary E Wilson

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
  2. Pathogens (Basel, Switzerland) · 2026
    Article
  3. Leishmaniasis.Nature reviews. Disease primers · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Using machine learning to dissect host kinases required forbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Peptide selection via phage display to inhibitFrontiers in microbiology · 2024
    Article
  12. Article
  13. Parasitology · 2023
    Article
  14. Total serumiScience · 2023
    Article
  15. Article
  16. Review
  17. Phenotypical Differences betweenPathogens (Basel, Switzerland) · 2023
    Article
  18. Article
  19. iScience · 2022
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Norikiyo UenoDepartment of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Mary E Wilson

Funding

Protective Immunity to Leishmania chagasiR01AI045540 · NIAID · UNIVERSITY OF IOWA · PI WILSON, MARY E · 2001 to 2011
$3.1M
Collaborative Development of a Vaccine against Cutaneous and Visceral LeishmaniasR01AI067874 · NIAID · UNIVERSITY OF IOWA · PI WILSON, MARY E · 2006 to 2010
$2.2M
Genetic Risk Factors for Visceral LeishmaniasisR01AI076233 · NIAID · UNIVERSITY OF IOWA · PI BLACKWELL, JENEFER MARY, WILSON, MARY E · 2009 to 2013
$1.6M
PHYS SCI RES TRAINING IN PATHOGENESIS OF VIRAL DISEASEST32AI007623 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIMON, VIVIANA A · 2000 to 2010
$1.2M
Innate inflammatory cells in leishmaniasisI01BX001983 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2014 to 2022
–
NIAID NIH HHS R01 AI045540NIAID NIH HHS R01 AI067874NIAID NIH HHS R01 AI07623NIAID NIH HHS R01 AI076233NIAID NIH HHS T32 AI007623
6 · The paper itself

Abstract

The extracellular promastigote stage of Leishmania spp. is transmitted to mammals by a sand fly vector. Leishmania promastigotes ligate host macrophage receptors, triggering phagocytosis and subsequent internalization, a crucial step for survival. Parasites transform intracellularly to the amastigote stage. Many studies document different receptors detecting promastigotes and amastigotes, but the relative importance of each interaction is ill-defined. Recent studies suggest that the macrophage receptors utilized during phagocytosis impact the intracellular fate of the parasite. This review summarizes the receptors implicated in Leishmania phagocytosis over the past 30 years. It then proceeds to weigh the evidence for or against their potential roles in intracellular parasite trafficking.

Indexed as

PhagocytosisReceptors, ImmunologicAnimalsAntigens, ProtozoanAntigens, SurfaceHumansLeishmaniaMacrophagesProtozoan ProteinsAntigens, ProtozoanAntigens, Surfacephagocytosis receptorProtozoan ProteinsReceptors, Immunologicsurface antigen P2, Leishmania

Identifiers

PMID22726697
PMCPMC3399048

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.