ArticleHearing research2012
Intrinsic modulators of auditory thalamocortical transmission.
Article in Hearing research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Cell-Type-Specific Expression of Leptin Receptors in the Mouse Forebrain.International journal of molecular sciences · 2024Article
- Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition.eLife · 2019Article
- Development, organization and plasticity of auditory circuits: Lessons from a cherished colleague.The European journal of neuroscience · 2019Review
- Inhibitory Projections in the Mouse Auditory Tectothalamic System.Brain sciences · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex.Brain sciences · 2016Article
- Thalamus plays a central role in ongoing cortical functioning.Nature neuroscience · 2016Review
- Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse thalamus.Journal of neurophysiology · 2015Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Differential expression of mGluR2 in the developing cerebral cortex of the mouse.Journal of biomedical science and engineering · 2014Article
- The function of metabotropic glutamate receptors in thalamus and cortex.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Laser-scanning photostimulation of optogenetically targeted forebrain circuits.Journal of visualized experiments : JoVE · 2013Article
- Functional convergence of thalamic and intrinsic projections to cortical layers 4 and 6.Neurophysiology · 2013Article
- Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.Neuroscience · 2013Article
- Thalamic and cortical pathways supporting auditory processing.Brain and language · 2013Review
- A modulatory effect of the feedback from higher visual areas to V1 in the mouse.Journal of neurophysiology · 2013Article
- Intracortical convergence of layer 6 neurons.Neuroreport · 2012Article
- Inhibition of mammillary body neurons by direct activation of Group II metabotropic glutamate receptors.Neurotransmitter (Houston, Tex.)Article
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Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons in layer 4 of the primary auditory cortex receive convergent glutamatergic inputs from thalamic and cortical projections that activate different groups of postsynaptic glutamate receptors. Of particular interest in layer 4 neurons are the Group II metabotropic glutamate receptors (mGluRs), which hyperpolarize neurons postsynaptically via the downstream opening of GIRK channels. This pronounced effect on membrane conductance could influence the neuronal processing of synaptic inputs, such as those from the thalamus, essentially modulating information flow through the thalamocortical pathway. To examine how Group II mGluRs affect thalamocortical transmission, we used an in vitro slice preparation of the auditory thalamocortical pathways in the mouse to examine synaptic transmission under conditions where Group II mGluRs were activated. We found that both pre- and post-synaptic Group II mGluRs are involved in the attenuation of thalamocortical EPSP/Cs. Thus, thalamocortical synaptic transmission is suppressed via the presynaptic reduction of thalamocortical neurotransmitter release and the postsynaptic inhibition of the layer 4 thalamorecipient neurons. This could enable the thalamocortical pathway to autoregulate transmission, via either a gating or gain control mechanism, or both.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.