ArticleBMC women's health2012
Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer.
Article in BMC women's health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Overweight and obesity increase breast cancer risk in postmenopausal women: a meta-analysis of 38 observational studies.GeroScience · 2026Pooled it
- Breast Cancer and Menopausal Hormone Therapy by Race/Ethnicity and Body Mass Index.Journal of the National Cancer Institute · 2016Pooled it
- Body mass index and breast cancer risk according to postmenopausal estrogen-progestin use and hormone receptor status.Epidemiologic reviews · 2014Pooled it
- Association of Occupational and Lifestyle Factors with Mammography-Detected Breast Neoplasia.Medical journal of the Islamic Republic of Iran · 2025Article
- Estrogen Receptor 1 Gene Polymorphism and its Association with Idiopathic Short Stature in a North Indian PopulationJournal of clinical research in pediatric endocrinology · 2024Article
- Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women.Scientific reports · 2022Article
- Interaction between common breast cancer susceptibility variants, genetic ancestry, and nongenetic risk factors in Hispanic women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Menopausal hormone therapy and breast cancer mortality: clinical implications.Therapeutic advances in drug safety · 2015Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer today has many established risk factors, both genetic and environmental, but these risk factors by themselves explain only part of the total cancer incidence. We have investigated potential interactions between certain known genetic and phenotypic risk factors, specifically nine single nucleotide polymorphisms (SNPs) and height, body mass index (BMI) and hormone replacement therapy (HRT).
methodsWe analyzed samples from three different study populations: two prospectively followed Swedish cohorts and one Icelandic case-control study. Totally 2884 invasive breast cancer cases and 4508 controls were analysed in the study. Genotypes were determined using Mass spectrometry-Maldi-TOF and phenotypic variables were derived from measurements and/or questionnaires. Odds Ratios and 95% confidence intervals were calculated using unconditional logistic regression with the inclusion of an interaction term in the logistic regression model.
resultsOne SNP (rs851987 in ESR1) tended to interact with height, with an increasingly protective effect of the major allele in taller women (p = 0.007) and rs13281615 (on 8q24) tended to confer risk only in non users of HRT (p-for interaction = 0.03). There were no significant interactions after correction for multiple testing.
conclusionsWe conclude that much larger sample sets would be necessary to demonstrate interactions between low-risk genetic polymorphisms and the phenotypic variables height, BMI and HRT on the risk for breast cancer. However the present hypothesis-generating study has identified tendencies that would be of interest to evaluate for gene-environment interactions in independent materials.
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