Evidence map›Paper›PMID 22724516›Full record

ArticleAging & mental health2013

Vascular depression: an early warning sign of frailty.

Daniel Paulson, Peter A Lichtenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging & mental health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Depression and frailty in later life: a systematic review.Clinical interventions in aging · 2015
    Pooled it
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  14. Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daniel PaulsonDepartment of Psychology, Institute of Gerontology, Wayne State University, Detroit, MI, USA. Paulson@wayne.edu
Peter A Lichtenberg
Wayne State University · US

Funding

Michigan Center for Urban African American Aging Research - RESEARCH CORE (REC)P30AG015281 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jaymia Ann Mitchell · 1997 to 2026
$19.3M
PRE-DOCTORAL RESEARCH TRAINING IN AGING &URBAN HEALTHT32AG000275 · NIA · WAYNE STATE UNIVERSITY · PI LICHTENBERG, PETER A. · 2001 to 2011
$1.9M
NIA NIH HHS P30 AG015281NIA NIH HHS T32 AG000275NIA NIH HHS T-32 AG00275-06
6 · The paper itself

Abstract

objectivesFrailty is a common geriatric disorder associated with activities of daily living (ADL) impairment, hospitalization, and death. Phenomenological evidence suggests that late-life depression (Katz, 2004 ), particularly vascular depression, may be a risk factor for frailty. This study tests that hypothesis.

methodsWe identified a sample of stroke-free women over the age of 80 from the Health and Retirement Survey. The sample included 984 respondents in 2000 (incidence sample). Of these, 459 were non-frail at baseline and still alive in 2004 (prevalence sample). Frail respondents experienced at least three of the following: wasting, exhaustion, weakness, slowness, and falls. Vascular depression was represented using two dummy variables. The first represented respondents with either high cerebrovascular burden (CVB; at least two cerebrovascular risk factors) or probable depression (score ≥3 on the 8-item Center for Epidemiological Studies Depression Scale (CES-D)), and the second represented respondents with both high CVB and probable depression.

resultsAt baseline, the prevalence of frailty was 31.5%. Over four years the incidence of frailty was 31.8%. After controlling for age, education, ADL and IADL disability, arthritis, pulmonary disorders, cancer, and self-rated health, respondents with either high CVB or probable depression were more likely to be frail at baseline, and those with both were at even higher risk. Of those who were not frail at the 2000 wave, respondents who reported both high CVB and probable depression were more likely to become frail by 2004. DISCUSSION: These findings suggest that vascular depression is a prodrome for frailty.

Indexed as

Activities of Daily LivingAgedAged, 80 and overAgingCerebrovascular DisordersDepressionFemaleFollow-Up StudiesFrail ElderlyGeriatric AssessmentHealth StatusHumansIncidenceLogistic ModelsMalePersons with Disabilities

Identifiers

PMID22724516
PMCPMC3492543
OpenAlexW2082746138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.