ArticleJournal of the American Geriatrics Society2012
Effect of influenza on functional decline.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High Dose Influenza Vaccination and Morbidity and Mortality in U.S. Nursing Homes - A Pilot Evaluation
High Dose Influenza Vaccination and Morbidity & Mortality in U.S. Nursing Homes
Who cites it
37 citing papers in PubMed, 81 citations in OpenAlex.
- Feasibility of a cluster-randomized influenza vaccination trial in U.S. nursing homes: Lessons learned.Human vaccines & immunotherapeutics · 2018Trial
- Article
- [Vaccination in old age: an overview].Zeitschrift fur Gerontologie und Geriatrie · 2023Article
- Article
- Assessing the patient experience of respiratory syncytial virus infection: development of a patient-reported outcome measure.Health and quality of life outcomes · 2023Review
- Predictions from standard epidemiological models of consequences of segregating and isolating vulnerable people into care facilities.PloS one · 2023Article
- Poverty, noncommunicable diseases, and perceived health risks among older adults during the COVID-19 pandemic in urban Thailand.Asian social work and policy review · 2022Article
- Nutritional and Functional Impact of Acute SARS-CoV-2 Infection in Hospitalized Patients.Journal of clinical medicine · 2022Article
- The dark side of Tregs during aging.Frontiers in immunology · 2022Review
- Geographic variation in influenza vaccination among U.S. nursing home residents: A national study.Journal of the American Geriatrics Society · 2021Article
- Risk Factors Associated with 30-Day Mortality in Older Patients with Influenza.Journal of clinical medicine · 2021Article
- Estimated Cardiorespiratory Hospitalizations Attributable to Influenza and Respiratory Syncytial Virus Among Long-term Care Facility Residents.JAMA network open · 2021Article
- Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans.Immunity & ageing : I & A · 2021Article
- Modeling Large Sparse Data for Feature Selection: Hospital Admission Predictions of the Dementia Patients Using Primary Care Electronic Health Records.IEEE journal of translational engineering in health and medicine · 2021Article
- Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Review
- Impaired phagocytic function in CX3CR1Aging cell · 2020Article
- [Respiratory viral infections (other than COVID-19)].Medecine et maladies infectieuses · 2020Article
- The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing.Aging clinical and experimental research · 2020Review
- Risk factors for pneumonia and influenza hospitalizations in long-term care facility residents: a retrospective cohort study.BMC geriatrics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo examine the relationship between influenza and activity of daily living (ADL) decline and other clinical indicators in nursing home (NH) residents.
designRetrospective NH-aggregated longitudinal study.
settingTwo thousand three hundred fifty-one NHs in 122 U.S. cities from 1999 to 2005.
participantsLong-stay (>90 days) NH residents. MEASUREMENTS: Quarterly city-level influenza mortality and state-level influenza severity. Quarterly incidence of Minimum Data Set-derived ADL decline (≥ 4 points), weight loss, new or worsening pressure ulcers (PUs), and infections. Outcome variables chosen as clinical controls were antipsychotic use, restraint use, and persistent pain.
resultsCity-level influenza mortality and state-level influenza severity were associated with higher rates of large (≥ 4 points) ADL decline (mortality β = 0.20, P < .001; severity β = 0.18, P < .001), weight loss (β = 0.19, P < .001; β = 0.24, P < .001), worsening PUs (β = 0.04, P = .08; β = 0.12, P < .001), and infections (β = 0.41, P < .001; β = 0.47, P < .001) but not with restraint use, antipsychotic use, or persistent pain. NH influenza vaccination rates were weakly associated with the outcomes (e.g., β = -0.009, P = .03 for ADL decline, β = 0.008, P = .07 for infections). Compared with the summer quarter of lowest influenza activity, the results for the other quarters translate to an additional 12,284 NH residents experiencing large ADL decline annually, 15,168 experiencing significant weight loss, 6,284 new or worsening PUs, and 29,753 experiencing infections due to influenza.
conclusionThe results suggest a substantial and potentially costly effect of influenza on NH residents. The effect of influenza vaccination on preventing further ADL decline and other clinical outcomes in NH residents should be studied further.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.