ArticlePloS one2012
Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects.Applied psychology. Health and well-being · 2022Pooled it
- Port of Choice: Induction Chamber Inlet Position Affects Speed of Isoflurane Induction in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Article
- Article
- Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.Anesthesiology · 2019Review
- Progesterone Application to the Rat Forehead Produces Corneal Antinociception.Investigative ophthalmology & visual science · 2019Article
- Layer- and subregion-specific differences in the neurophysiological properties of rat medial prefrontal cortex pyramidal neurons.Journal of neurophysiology · 2018Article
- Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?PloS one · 2018Article
- Optogenetic induction of cortical spreading depression in anesthetized and freely behaving mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- The effect of light level, CO2 flow rate, and anesthesia on the stress response of mice during CO2 euthanasia.Lab animal · 2016Article
- Optogenetic Functional MRI.Journal of visualized experiments : JoVE · 2016Article
- Sensory encoding in Neuregulin 1 mutants.Brain structure & function · 2016Article
- Inhibition of astrocyte metabolism is not the primary mechanism for anaesthetic hypnosis.SpringerPlus · 2016Article
- Inhibitory luminopsins: genetically-encoded bioluminescent opsins for versatile, scalable, and hardware-independent optogenetic inhibition.Scientific reports · 2015Article
- The general anesthetic propofol induces ictal-like seizure activity in hippocampal mouse brain slices.SpringerPlus · 2015Article
- Preferential effect of isoflurane on top-down vs. bottom-up pathways in sensory cortex.Frontiers in systems neuroscience · 2014Article
- Microelectrode arrays in combination with in vitro models of spinal cord injury as tools to investigate pathological changes in network activity: facts and promises.Frontiers in neuroengineering · 2013Article
- Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.The Journal of clinical investigation · 2012Article
- Anesthetics interfere with the polarization of developing cortical neurons.Journal of neurosurgical anesthesiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.