ArticlePloS one2012
Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Complement defects in patients with chronic rhinosinusitis.PloS one · 2012Trial
- Histone H3 lysine 9 tri-methylation is associated with pterygium.BMC ophthalmology · 2025Article
- The chemistry of gut microbiome-derived lipopolysaccharides impacts on the occurrence of food allergy in the pediatric age.Frontiers in molecular biosciences · 2023Article
- White blood cells and chronic rhinosinusitis: a Mendelian randomization study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.ACS pharmacology & translational science · 2022Article
- The identification of novel gene mutations for degenerative lumbar spinal stenosis using whole-exome sequencing in a Chinese cohort.BMC medical genomics · 2021Article
- Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.The Journal of biological chemistry · 2020Review
- Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.Allergy, asthma & immunology research · 2020Review
- AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study.PloS one · 2020Article
- LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma.The Journal of experimental medicine · 2018Article
- Crystal structure of the mammalian lipopolysaccharide detoxifier.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- OrfX, a Nucleomodulin Required formBio · 2017Article
- Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury.PLoS pathogens · 2017Article
- Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis.Annual review of pathology · 2017Review
- Expression and clinical significance of PcG-associated protein RYBP in hepatocellular carcinoma.Oncology letters · 2017Article
- Molecular mechanisms of nasal epithelium in rhinitis and rhinosinusitis.Current allergy and asthma reports · 2015Review
- Risk factors for chronic rhinosinusitis.Current opinion in allergy and clinical immunology · 2015Review
- Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors.
objectivesTo replicate and extend our recent findings from genetic association studies in chronic rhinosinusitis (CRS) performed in a Canadian Caucasian population in a Chinese population.
methodsIn a case-control replication study, DNA samples were obtained from CRS with (n = 306; CRSwNP) and without (n = 332; CRSsNP) nasal polyps, and controls (n = 315) in a Chinese population. A total of forty-nine single nucleotide polymorphisms (SNPs) selected from previous identified SNPs associated with CRS in Canadian population, and SNPs from the CHB HapMap dataset were individually genotyped.
resultsWe identified two SNPs respectively in RYBP (rs4532099, p = 2.15E-06, OR = 2.59) and AOAH (rs4504543, p = 0.0001152, OR = 0.58) significantly associated with whole CRS cohort. Subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP) displayed significant association in CRSwNP cohorts regarding to one SNP in RYBP (P = 3.24(E)-006, OR = 2.76). Evidence of association in the CRSsNP groups in terms of 2 SNPs (AOAH_rs4504543 and RYBP_rs4532099) was detected as well. Stratifying analysis by gender demonstrated that none of the selected SNPs were associated with CRSwNP as well as CRSsNP. Meanwhile 3 SNPs (IL1A_rs17561, P = 0.005778; IL1A_rs1800587, P = 0.009561; IRAK4_rs4251513, P = 0.03837) were associated with serum total IgE level.
conclusionsThese genes are biologically plausible, with roles in regulation of transcription (RYBP) and inflammatory response (AOAH). The present data suggests the potential common genetic basis in the development of CRS in Chinese and Caucasian population.
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