ArticlePloS one2012
DNA-methylation profiling of fetal tissues reveals marked epigenetic differences between chorionic and amniotic samples.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Microarray-Based Analysis of Methylation of 1st Trimester Trisomic Placentas from Down Syndrome, Edwards Syndrome and Patau Syndrome.PloS one · 2016Trial
- Placental biomarkers for the prediction of neurodevelopmental disorders.Frontiers in cell and developmental biology · 2025Review
- Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.BMC genomics · 2021Article
- Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary view.Expert reviews in molecular medicine · 2021Article
- Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome.Trends in molecular medicine · 2020Article
- Fetal Membrane Epigenetics.Frontiers in physiology · 2020Review
- Genetic and epigenetic pathways in Down syndrome: Insights to the brain and immune system from humans and mouse models.Progress in brain research · 2020Review
- Global impacts of chromosomal imbalance on gene expression inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates.PloS one · 2018Article
- Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models.Epigenomics · 2017Review
- Expression patterns of the chromosome 21 MicroRNA cluster (miR-99a, miR-125b and let-7c) in chorioamniotic membranes.Placenta · 2017Article
- Genome-Wide Epigenetic Characterization of Tissues from Three Germ Layers Isolated from Sheep Fetuses.Frontiers in genetics · 2017Article
- Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling.Prenatal diagnosis · 2016Article
- Candidate Gene and MicroRNA Expression in Fetal Membranes and Preterm Delivery Risk.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Identification of a DNA methylation signature in blood cells from persons with Down Syndrome.Aging · 2015Article
- Article
- Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Frequency and characterization of DNA methylation defects in children born SGA.European journal of human genetics : EJHG · 2013Article
- Global DNA hypermethylation in down syndrome placenta.PLoS genetics · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mechanisms including DNA methylation are supposed to play a key role in fetal development. Here we have investigated fetal DNA-methylation levels of 27,578 CpG loci in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. Methylation levels differed significantly between karyotypically normal AC and CVS for 2,014 genes. AC showed more extreme DNA-methylation levels of these genes than CVS and the differentially methylated genes are significantly enriched for processes characteristic for the different cell types sampled. Furthermore, we identified 404 genes differentially methylated in CVS with trisomy 21. These genes were significantly enriched for high CG dinucleotid (CpG) content and developmental processes associated with Down syndrome. Our study points to major tissue-specific differences of fetal DNA-methylation and gives rise to the hypothesis that part of the Down syndrome phenotype is epigenetically programmed in the first trimester of pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.