ArticleFrontiers in neurology2012
Delirium in elderly people: a review.
Article in Frontiers in neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Working From Dusk to Dawn: A Joy or Nightmare.Orthopedic nursingPooled it
- Efficacy of quetiapine for delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial.BMC geriatrics · 2021Trial
- Fast-track surgery decreases the incidence of postoperative delirium and other complications in elderly patients with colorectal carcinoma.Langenbeck's archives of surgery · 2014Trial
- Delirium in older hospitalized patients: a decade-later study highlighting medical and medication-related etiologies beyond muscarinic antagonism.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study.BMC medicine · 2026Article
- Risk factors associated with cancer and metabolic encephalopathy in Alzheimer's disease patients.Frontiers in aging neuroscience · 2026Article
- Point-of-care electroencephalography for prediction of postoperative delirium in older adults undergoing elective surgery: protocol for a prospective cohort study.Biology methods & protocols · 2026Review
- Artificial intelligence in drug development for delirium and Alzheimer's disease.Acta pharmaceutica Sinica. B · 2025Review
- Delirium Prevention and Management in Older Adults in the Emergency Department.Emergency medicine clinics of North America · 2025Review
- Lipopolysaccharide-Induced Delirium-Like Behavior and Microglial Activation in Mice Correlate With Bispectral Electroencephalography.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Delirium in Lower Limb Trauma: The Incidence and Risk Factors in a Prospective Observational Study.Indian journal of orthopaedics · 2024Article
- Investigation of Post-Transplant Mental Well-Being in Liver Transplant Recipients with Hepatic Encephalopathy.Journal of clinical medicine · 2024Article
- Identification of risk factors for the onset of delirium associated with COVID-19 by mining nursing records.PloS one · 2024Article
- Innovative Non-Pharmacological Management of Delirium in Persons with Dementia: New Frontiers for Physiotherapy and Occupational Therapy?Geriatrics (Basel, Switzerland) · 2023Review
- The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation.Frontiers in neuroscience · 2023Article
- Psychogenic coma after general anesthesia with remimazolam and remifentanil -a case report.Korean journal of anesthesiology · 2022Article
- A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome.Molecular psychiatry · 2021Article
- The effect of multi-component interventions on the incidence rate, severity, and duration of post open heart surgery delirium among hospitalized patients.Journal of cardiothoracic surgery · 2021Article
- Silent cognitive frailty at the interplay between delirium and COVID-19.Asian journal of psychiatry · 2021Article
- Observational
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present review aims to highlight this intricate syndrome, regarding diagnosis, pathophysiology, etiology, prevention, and management in elderly people. The diagnosis of delirium is based on clinical observations, cognitive assessment, physical, and neurological examination. Clinically, delirium occurs in hyperactive, hypoactive, or mixed forms, based on psychomotor behavior. As an acute confusional state, it is characterized by a rapid onset of symptoms, fluctuating course and an altered level of consciousness, global disturbance of cognition or perceptual abnormalities, and evidence of a physical cause. Although pathophysiological mechanisms of delirium remain unclear, current evidence suggests that disruption of neurotransmission, inflammation, or acute stress responses might all contribute to the development of this ailment. It usually occurs as a result of a complex interaction of multiple risk factors, such as cognitive impairment/dementia and current medical or surgical disorder. Despite all of the above, delirium is frequently under-recognized and often misdiagnosed by health professionals. In particular, this happens due to its fluctuating nature, its overlap with dementia and the scarcity of routine formal cognitive assessment in general hospitals. It is also associated with multiple adverse outcomes that have been well documented, such as increased hospital stay, function/cognitive decline, institutionalization and mortality. In this context, the early identification of delirium is essential. Timely and optimal management of people with delirium should be performed with identification of any possible underlying causes, dealing with a suitable care environment and improving education of health professionals. All these can be important factors, which contribute to a decrease in adverse outcomes associated with delirium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.