Evidence map›Paper›PMID 22723786›Full record

ArticleFrontiers in psychiatry2012

Effects of frontal transcranial direct current stimulation on emotional state and processing in healthy humans.

M A Nitsche, J Koschack, H Pohlers, S Hullemann, W Paulus, S Happe

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05623072 (The Effect of tDCS on Emotion Recognition and EEG Oscillations in Healthy Adults), which is not on this map. Cited by 66 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05623072 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of tDCS on Emotion Recognition and EEG Oscillations in Healthy Adults

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2022 to 2023Enrolled56ConditionsEmotion RecognitionArmsActive tDCS, Sham tDCS
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020
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  8. The efficacy of transcranial random noise stimulation (tRNS) on mood may depend on individual differences including age and trait mood.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M A NitscheDepartment Clinical Neurophysiology, Georg-August-University Goettingen, Germany.
J Koschack
H Pohlers
S Hullemann
W Paulus
S Happe

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prefrontal cortex is involved in mood and emotional processing. In patients suffering from depression, the left dorsolateral prefrontal cortex (DLPFC) is hypoactive, while activity of the right DLPFC is enhanced. Counterbalancing these pathological excitability alterations by repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) improves mood in these patients. In healthy subjects, however, rTMS of the same areas has no major effect, and the effects of tDCS are mixed. We aimed to evaluate the effects of prefrontal tDCS on emotion and emotion-related cognitive processing in healthy humans. In a first study, we administered excitability-enhancing anodal, excitability-diminishing cathodal, and placebo tDCS to the left DLPFC, combined with antagonistic stimulation of the right frontopolar cortex, and tested acute emotional changes by an adjective checklist. Subjective emotions were not influenced by tDCS. Emotional face identification, however, which was explored in a second experiment, was subtly improved by a tDCS-driven excitability modulation of the prefrontal cortex, markedly by anodal tDCS of the left DLPFC for positive emotional content. We conclude that tDCS of the prefrontal cortex improves emotion processing in healthy subjects, but does not influence subjective emotional state.

Indexed as

brainemotionface recognitionhumanprefrontal cortex

Identifiers

PMID22723786
PMCPMC3377009

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.