ArticleFood & nutrition research2012
High hydrostatic pressure pre-treatment of whey proteins enhances whey protein hydrolysate inhibition of oxidative stress and IL-8 secretion in intestinal epithelial cells.
Article in Food & nutrition research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 108 citations in OpenAlex.
- Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial.Respiratory research · 2020Trial
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- Nutritional and functional enhancement of cottonseed meal via diverse processing techniques as soybean meal alternatives in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Bioactive milk peptides: an updated comprehensive overview and database.Critical reviews in food science and nutrition · 2024Review
- Dairy, Plant, and Novel Proteins: Scientific and Technological Aspects.Foods (Basel, Switzerland) · 2024Review
- Evaluation of the Effects of Whey Protein and Moringa Oleifera Leaves Extract Mixture on Osseointegration in Rabbits.Iranian biomedical journal · 2024Article
- Effect of Milk Origin and Seasonality of Yogurt Acid Whey on Antioxidant Activity before and after In Vitro Gastrointestinal Digestion.Antioxidants (Basel, Switzerland) · 2023Article
- Antioxidant Activity of Sweet Whey Derived from Bovine, Ovine and Caprine Milk Obtained from Various Small-Scale Cheese Plants in Greece before and after In Vitro Simulated Gastrointestinal Digestion.Antioxidants (Basel, Switzerland) · 2023Article
- Potential Application of High Hydrostatic Pressure on the Production of Hydrolyzed Proteins with Antioxidant and Antihypertensive Properties and Low Allergenicity: A Review.Foods (Basel, Switzerland) · 2023Review
- Significance of whey protein hydrolysate on anti-oxidative, ACE-inhibitory and anti-inflammatory activities and release of peptides with biofunctionality: an in vitro and in silico approach.Journal of food science and technology · 2022Article
- Comparative Study on the Exacerbating Effects of Casein-Rich vs. Gluten-Rich Diets on Biochemical-Induced Features in Rodent Model of Autism.Journal of molecular neuroscience : MN · 2022Article
- Food-derived bioactive oligopeptide iron complexes ameliorate iron deficiency anemia and offspring development in pregnant rats.Frontiers in nutrition · 2022Article
- Conventional and Novel Technologies in the Production of Dairy Bioactive Peptides.Frontiers in nutrition · 2022Review
- Copper-Binding Peptides Attenuate Microglia Inflammation through Suppression of NF-kB Pathway.Molecular nutrition & food research · 2021Article
- The effects of baths and wet wraps with a sweet whey solution on the level of hydration and barrier function of the epidermis.Postepy dermatologii i alergologii · 2021Article
- Depletion of the gut microbiota differentially affects the impact of whey protein on high-fat diet-induced obesity and intestinal permeability.Physiological reports · 2021Article
- Current Evidence on the Bioavailability of Food Bioactive Peptides.Molecules (Basel, Switzerland) · 2020Review
- In Vitro Characterisation of the Antioxidative Properties of Whey Protein Hydrolysates Generated under pH- and Non pH-Controlled Conditions.Foods (Basel, Switzerland) · 2020Article
- Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis.Nutrients · 2019Review
- PulmonaryFood & nutrition research · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh hyperbaric pressure treatment of whey protein isolate (WPI) causes changes in the protein structure that enhances the anti-oxidant and anti-inflammatory effects of WPI.
objectiveThe aim of this study was to compare the anti-oxidant and anti-inflammatory effects of pressurized whey protein isolate (pWPI) vs. native WPI (nWPI) hydrolysates in Caco-2 cells exposed to hydrogen peroxide (H(2)O(2)).
designCells were cultured with different concentrations of pWPI or nWPI hydrolysates either 1 h before or 1 h after H(2)O(2). Cell viability, IL-8 secretion, intracellular reactive oxygen species (ROS), and the medium anti-oxidant capacity (FRAP assay) were measured.
resultsPrior to and after H(2)O(2) exposure, pWPI and nWPI hydrolysates inhibited IL-8 secretion and ROS generation, and increased FRAP activity in a dose-dependent manner. The maximal inhibition of H(2)O(2)-induced IL-8 secretion was greater with 2000 µg mL(-1) of pWPI (50%) vs. nWPI (30%) hydrolysates. At the latter concentration, inhibition of H(2)O(2)-induced ROS formation reached 76% for pWPI, which was greater than for nWPI hydrolysates (32.5%).
conclusionsThese results suggest that WPI hydrolysates can alleviate inflammation and oxidative stress in intestinal cells exposed to oxidative injury, which is further enhanced by hyperbaric pressure pre-treatment of WPI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.