Evidence map›Paper›PMID 22723722›Full record

ArticleMaterials Research Society symposia proceedings. Materials Research Society2011

Quantifying Micro-mechanical Properties of Soft Biological Tissues with Scanning Acoustic Microscopy.

Xuegen Zhao, Steven Wilkinson, Riaz Akhtar, Michael J Sherratt, Rachel E B Watson, Brian Derby

Abstract read
In one paragraph

Article in Materials Research Society symposia proceedings. Materials Research Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuegen ZhaoSchool of Materials, the University of Manchester, Manchester, M1 7HS, United Kingdom.
Steven Wilkinson
Riaz Akhtar
Michael J Sherratt
Rachel E B Watson
Brian Derby

Funding

Wellcome Trust 085981
6 · The paper itself

Abstract

In this study we have established a new approach to more accurately map acoustic wave speed (which is a measure of stiffness) within soft biological tissues at micrometer length scales using scanning acoustic microscopy. By using thin (5 μm thick) histological sections of human skin and porcine cartilage, this method exploits the phase information preserved in the interference between acoustic waves reflected from the substrate surface as well as internal reflections from the acoustic lens. A stack of images were taken with the focus point of acoustic lens positioned at or above the substrate surface, and processed pixel by pixel using custom software developed with LABVIEW and IMAQ (National Instruments) to extract phase information. Scanning parameters, such as acoustic wave frequency and gate position were optimized to get reasonable phase and lateral resolution. The contribution from substrate inclination or uneven scanning surface was removed prior to further processing. The wave attenuation was also obtained from these images.

Identifiers

PMID22723722
PMCPMC3378028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.