ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Gene network effects on brain microstructure and intellectual performance identified in 472 twins.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.Brain imaging and behavior · 2014Pooled it
- Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.Brain imaging and behavior · 2013Pooled it
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth.Translational psychiatry · 2022Article
- A Probabilistic Atlas of the Pineal Gland in the Standard Space.Frontiers in neuroinformatics · 2021Article
- Brain Imaging Genomics: Integrated Analysis and Machine Learning.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2020Article
- Genetic relatedness of axial and radial diffusivity indices of cerebral white matter microstructure in late middle age.Human brain mapping · 2018Article
- Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder.Molecular psychiatry · 2018Article
- Neuroimaging genomics in psychiatry-a translational approach.Genome medicine · 2017Review
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
- Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Generalized reduced rank latent factor regression for high dimensional tensor fields, and neuroimaging-genetic applications.NeuroImage · 2017Article
- Quantifying Differences and Similarities in Whole-Brain White Matter Architecture Using Local Connectome Fingerprints.PLoS computational biology · 2016Article
- Heritability of the limbic networks.Social cognitive and affective neuroscience · 2016Article
- The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects.NeuroImage · 2016Article
- Head Motion and Inattention/Hyperactivity Share Common Genetic Influences: Implications for fMRI Studies of ADHD.PloS one · 2016Article
- Cracking the brain's genetic code.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Development of the brain's structural network efficiency in early adolescence: A longitudinal DTI twin study.Human brain mapping · 2015Article
- Genetics and brain morphology.Neuropsychology review · 2015Article
- Genome-wide interaction analysis reveals replicated epistatic effects on brain structure.Neurobiology of aging · 2015Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
A major challenge in neuroscience is finding which genes affect brain integrity, connectivity, and intellectual function. Discovering influential genes holds vast promise for neuroscience, but typical genome-wide searches assess approximately one million genetic variants one-by-one, leading to intractable false positive rates, even with vast samples of subjects. Even more intractable is the question of which genes interact and how they work together to affect brain connectivity. Here, we report a novel approach that discovers which genes contribute to brain wiring and fiber integrity at all pairs of points in a brain scan. We studied genetic correlations between thousands of points in human brain images from 472 twins and their nontwin siblings (mean age: 23.7 ± 2.1 SD years; 193 male/279 female). We combined clustering with genome-wide scanning to find brain systems with common genetic determination. We then filtered the image in a new way to boost power to find causal genes. Using network analysis, we found a network of genes that affect brain wiring in healthy young adults. Our new strategy makes it computationally more tractable to discover genes that affect brain integrity. The gene network showed small-world and scale-free topologies, suggesting efficiency in genetic interactions and resilience to network disruption. Genetic variants at hubs of the network influence intellectual performance by modulating associations between performance intelligence quotient and the integrity of major white matter tracts, such as the callosal genu and splenium, cingulum, optic radiations, and the superior longitudinal fasciculus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.