ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Low-frequency stimulation depresses the primate anterior-cingulate-cortex and prevents spontaneous recovery of aversive memories.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Modulation of fear extinction processes using transcranial electrical stimulation.Translational psychiatry · 2016Trial
- How Administration of the Beta-Blocker Propranolol Before Extinction can Prevent the Return of Fear.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.Biomedicines · 2022Review
- Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.The Journal of comparative neurology · 2021Article
- Improving cognitive task in kindled rats by using low frequency stimulation during epileptogenesis.Metabolic brain disease · 2018Article
- Cerebellar Theta-Burst Stimulation Impairs Memory Consolidation in Eyeblink Classical Conditioning.Neural plasticity · 2018Article
- Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex.Nature neuroscience · 2017Article
- The influence of self-awareness on emotional memory formation: an fMRI study.Social cognitive and affective neuroscience · 2016Article
- Amygdala-prefrontal interactions in (mal)adaptive learning.Trends in neurosciences · 2015Review
- Encoding of fear learning and memory in distributed neuronal circuits.Nature neuroscience · 2014Review
- Animal models of fear relapse.ILAR journal · 2014Review
- Activity in prelimbic cortex subserves fear memory reconsolidation over time.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Safety signals in the primate amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Physiological basis for emotional modulation of memory circuits by the amygdala.Current opinion in neurobiology · 2013Review
- Double dissociation between the anterior cingulate cortex and nucleus accumbens core in encoding the context versus the content of pavlovian cocaine cue extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional abnormalities in the dorsal-anterior-cingulate-cortex (dACC) underlie anxiety disorders and specifically post-traumatic stress disorder (PTSD). Promising and common behavioral approaches have limited effectiveness and many subjects exhibit spontaneous recovery of fear, as also evident in animal models following extinction training. Here, we use low-frequency stimulation (LFS), a protocol shown to induce long-term depression, with the aim of affecting synaptic plasticity induced by fear acquisition and extinction. We use aversive conditioning of either tone or visual stimuli paired with an aversive air-puff to the eye in a trace-conditioning paradigm. We find that LFS in the nonhuman primate (Macaca fascicularis) dACC, when combined with extinction training, was successful in preventing spontaneous recovery of the memory 24-72 h following extinction. We simultaneously record single-units and local-field-potentials across the dACC, and show that LFS gradually depressed evoked responses. Moreover, this decrease in neural excitability predicted the successful reduction of overnight spontaneous recovery on a day-by-day basis. Finally, we show that this effect occurs when using either visual or auditory modality as the conditioned stimulus, and that the reduction was specific to the conditioned modality. Our results suggest that the primate dACC is actively involved in maintaining the original aversive memory, and propose that a combination of LFS with behavioral therapy might significantly improve treatment in severe cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.