ArticleJournal of neurophysiology2012
Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 136 citations in OpenAlex.
- Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei: a pharmacological fMRI study.The Journal of investigative dermatology · 2015Trial
- Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026Review
- Spinal and supraspinal mechanisms of chronic itch: from neuronal circuits to the neuro-immune-microbial axis.Frontiers in medicine · 2026Review
- Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025Review
- Kappa opioids inhibit spinal output neurons to suppress itch.Science advances · 2024Article
- Identification of a convergent spinal neuron population that encodes itch.bioRxiv : the preprint server for biology · 2023Article
- Research Progress on the Mechanisms of Central Post-Stroke Pain: A Review.Cellular and molecular neurobiology · 2023Review
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- Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord.Frontiers in molecular neuroscience · 2023Article
- Pruritus and urticaria induced by neurostimulation: A case report and review of literature.Surgical neurology international · 2023Article
- Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterisation of deep dorsal horn projection neurons in the spinal cord of the Phox2a::Cre mouse line.Molecular pain · 2022Article
- Modulation of itch and pain signals processing in ventrobasal thalamus by thalamic reticular nucleus.iScience · 2022Article
- The Spino-Parabrachial Pathway for Itch.Frontiers in neural circuits · 2022Review
- Chronic itch induced by thalamic deep brain stimulation: a case for a central itch centre.Journal of translational medicine · 2021Observational
- Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- How Do Neurons Signal Itch?Frontiers in medicine · 2021Review
- Neuropathic Itch.Cells · 2020Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Itch of peripheral origin requires information transfer from the spinal cord to the brain for perception. Here, primate spinothalamic tract (STT) neurons from lumbar spinal cord were functionally characterized by in vivo electrophysiology to determine the role of these cells in the transmission of pruriceptive information. One hundred eleven STT neurons were identified by antidromic stimulation and then recorded while histamine and cowhage (a nonhistaminergic pruritogen) were sequentially applied to the cutaneous receptive field of each cell. Twenty percent of STT neurons responded to histamine, 13% responded to cowhage, and 2% responded to both. All pruriceptive STT neurons were mechanically sensitive and additionally responded to heat, intradermal capsaicin, or both. STT neurons located in the superficial dorsal horn responded with greater discharge and longer duration to pruritogens than STT neurons located in the deep dorsal horn. Pruriceptive STT neurons discharged in a bursting pattern in response to the activating pruritogen and to capsaicin. Microantidromic mapping was used to determine the zone of termination for pruriceptive STT axons within the thalamus. Axons from histamine-responsive and cowhage-responsive STT neurons terminated in several thalamic nuclei including the ventral posterior lateral, ventral posterior inferior, and posterior nuclei. Axons from cowhage-responsive neurons were additionally found to terminate in the suprageniculate and medial geniculate nuclei. Histamine-responsive STT neurons were sensitized to gentle stroking of the receptive field after the response to histamine, suggesting a spinal mechanism for alloknesis. The results show that pruriceptive information is encoded by polymodal STT neurons in histaminergic or nonhistaminergic pathways and transmitted to the ventrobasal complex and posterior thalamus in primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.