ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Dynamic interaction between the heart and its sympathetic innervation following T5 spinal cord transection.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Neural Regulation of Cardiac Arrhythmias: From the Brain-Heart Axis to Emerging Precision Therapies.Research (Washington, D.C.) · 2026Review
- "Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function".bioRxiv : the preprint server for biology · 2025Article
- The susceptibility of cardiac arrhythmias after spinal cord crush injury in rats.Experimental neurology · 2022Article
- Cardiac arrhythmias six months following traumatic spinal cord injury.The journal of spinal cord medicine · 2022Observational
- Distinct morphology of cardiac- and brown adipose tissue-projecting neurons in the stellate ganglia of mice.Physiological reports · 2022Article
- Article
- What gets on the nerves of cardiac patients? Pathophysiological changes in cardiac innervation.The Journal of physiology · 2022Article
- Loss of Cervical Sympathetic Chain Input to the Superior Cervical Ganglia Affects the Ventilatory Responses to Hypoxic Challenge in Freely-Moving C57BL6 Mice.Frontiers in physiology · 2021Article
- Direct comparison of cervical and high thoracic spinal cord injury reveals distinct autonomic and cardiovascular consequences.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Spinal cord injury alters purinergic neurotransmission to mesenteric arteries in rats.American journal of physiology. Heart and circulatory physiology · 2020Article
- Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat.American journal of physiology. Heart and circulatory physiology · 2019Article
- Chronic, complete cervicalJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Temporal analysis of cardiovascular control and function following incomplete T3 and T10 spinal cord injury in rodents.Physiological reports · 2018Article
- Spinal Cord Injury Causes Systolic Dysfunction and Cardiomyocyte Atrophy.Journal of neurotrauma · 2018Article
- Challenging cardiac function post-spinal cord injury with dobutamine.Autonomic neuroscience : basic & clinical · 2018Review
- A comparison of passive hindlimb cycling and active upper-limb exercise provides new insights into systolic dysfunction after spinal cord injury.American journal of physiology. Heart and circulatory physiology · 2017Article
- Autonomic dysreflexia: a cardiovascular disorder following spinal cord injury.Neural regeneration research · 2017Review
- BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.Developmental neurobiology · 2016Article
- Rigid and remodelled: cerebrovascular structure and function after experimental high-thoracic spinal cord transection.The Journal of physiology · 2016Article
- Central vs. peripheral neuraxial sympathetic control of porcine ventricular electrophysiology.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Midthoracic spinal cord injury (SCI) is associated with enhanced sympathetic support of heart rate as well as myocardial damage related to calcium overload. The myocardial damage may elicit an enhanced sympathetic support of contractility to maintain ventricular function. In contrast, the level of inotropic drive may be reduced to match the lower afterload that results from the injury-induced reduction in arterial pressure. Accordingly, the inotropic response to midthoracic SCI may be increased or decreased but has not been investigated and therefore remains unknown. Furthermore, the altered ventricular function may be associated with anatomical changes in cardiac sympathetic innervation. To determine the inotropic drive following midthoracic SCI, a telemetry device was used for repeated measurements of left ventricular (LV) function, with and without beta-adrenergic receptor blockade, in rats before and after midthoracic SCI or sham SCI. In addition, NGF content (ELISA) and dendritic arborization (cholera toxin B immunohistochemistry and Sholl analysis) of cardiac-projecting sympathetic postganglionic neurons in the stellate ganglia were determined. Midthoracic SCI was associated with an enhanced sympathetic support of heart rate, dP/dt(+), and dP/dt(-). Importantly, cardiac function was lower following blockade of the sympathetic nervous system in rats with midthoracic SCI compared with sham-operated rats. Finally, these functional neuroplastic changes were associated with an increased NGF content and structural neuroplasticity within the stellate ganglia. Results document impaired LV function with codirectional changes in chronotropic and inotropic responses following midthoracic SCI. These functional changes were associated with a dynamic interaction between the heart and its sympathetic innervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.