ArticleArteriosclerosis, thrombosis, and vascular biology2012
High-resolution association mapping of atherosclerosis loci in mice.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities.Current atherosclerosis reports · 2017Review
- Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis.Current opinion in lipidology · 2015Review
- The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice.Stem cell reports · 2015Article
- Transmission of atherosclerosis susceptibility with gut microbial transplantation.The Journal of biological chemistry · 2015Article
- Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis.Journal of lipid research · 2015Article
- Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.Physiological reports · 2014Article
- Article
- Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.Cell metabolism · 2013Article
- Genome-wide association studies in mice.Nature reviews. Genetics · 2012Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to fine map previously identified quantitative trait loci affecting atherosclerosis in mice using association analysis. METHODS AND
resultsWe recently showed that high-resolution association analysis using common inbred strains of mice is feasible if corrected for population structure. To use this approach for atherosclerosis, which requires a sensitizing mutation, we bred human apolipoprotein B-100 transgenic mice with 22 different inbred strains to produce F1 heterozygotes. Mice carrying the dominant transgene were tested for association with high-density single nucleotide polymorphism maps. Here, we focus on high-resolution mapping of the previously described atherosclerosis 30 locus on chromosome 1. Compared with the previous linkage analysis, association improved the resolution of the atherosclerosis 30 locus by more than an order of magnitude. Using expression quantitative trait locus analysis, we identified one of the genes in the region, desmin, as a strong candidate.
conclusionsOur high-resolution mapping approach accurately identifies and fine maps known atherosclerosis quantitative trait loci. These results suggest that high-resolution genome-wide association analysis for atherosclerosis is feasible in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.