ArticleAJNR. American journal of neuroradiology2013
Location of the clot and outcome of perfusion defects in acute anterior circulation stroke treated with intravenous thrombolysis.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Location-Specific ASPECTS Paradigm in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2020Pooled it
- Trial
- Thrombus Migration After Tenecteplase Versus Alteplase in Acute Large Vessel Occlusion.Journal of stroke · 2026Article
- Thrombus Imaging Features for Anterior Circulation Stroke: Their Impact on CTP Parameters and Natural Evolution of Infarct Progression.Journal of personalized medicine · 2025Article
- Review
- Computed tomography perfusion and computed tomography angiography for prediction of clinical outcomes in ischemic stroke patients after thrombolysis.Neural regeneration research · 2017Article
- Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients.Scientific reports · 2016Article
- Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions.Experimental and therapeutic medicine · 2016Article
- Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities.Journal of neurosurgery · 2016Article
- Distance to thrombus on MR angiography predicts outcome of middle cerebral artery occlusion treated with IV thrombolysis.Neuroradiology · 2015Article
- Thrombosis: Novel nanomedical concepts of diagnosis and treatment.World journal of cardiology · 2015Article
- Contribution and additional impact of imaging to the SPAN-100 score.AJNR. American journal of neuroradiology · 2015Article
- Collateral score complements clot location in predicting the outcome of intravenous thrombolysis.AJNR. American journal of neuroradiology · 2014Article
- 4D CT angiography more closely defines intracranial thrombus burden than single-phase CT angiography.AJNR. American journal of neuroradiology · 2013Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe location of the clot is a major determinant of ischemic stroke outcome. We studied the impact of the location (ICA, proximal M1 segment of the MCA, distal M1 segment, and M2 segment and more distally) of the clot on the CT perfusion parametric maps, the mismatch ratio, the amount of salvaged brain tissue, and the imaging and clinical outcomes in a retrospective acute (<3 hours) stroke cohort treated with intravenous thrombolysis. MATERIALS AND
methodsWe reviewed 105 patients who underwent admission multimodal CT that revealed an occluded vessel on CTA. CT perfusion was successfully performed in 58 patients (55%). Differences among the parameters in different vessel positions were studied with the ANCOVA by using onset-to-imaging time as a covariate followed by pair-wise testing.
resultsThere were no significant differences in potential confounding variables among the groups. A clot proximal to the M2 segment produced a significantly larger defect on the MTT map. A clot in the ICA resulted in a significantly larger CBV lesion compared with the distal M1 segment, the M2 segment, and the M3 segment. In general, a more proximal thrombus created a larger CBV defect. The fraction of penumbra that was salvaged at 24 hours was higher in the more distal vessel positions.
conclusionsAdmission CBV defects are larger in proximal vessel occlusions. More of the penumbra can be salvaged if the occlusion is located distally. This effect seems to reach a plateau in the distal M1 segment of the MCA.
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