ArticleJournal of gastroenterology2012
Live Helicobacter pylori in the root canal of endodontic-infected deciduous teeth.
Article in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Association between oral diseases and oral Helicobacter pylori infection: A systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Oral Helicobacter pylori: a scoping review and pilot study on the PCR-culture detection paradox.Clinical oral investigations · 2026Article
- Review
- Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection.International dental journal · 2025Article
- Co-culture of Helicobacter pylori with oral microorganisms in human saliva.Clinical oral investigations · 2025Article
- Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Effect ofJournal of oral microbiology · 2025Article
- Viable but non-cultivable state in oral microbiota: a critical review of an underexplored microbial survival strategy.Frontiers in cellular and infection microbiology · 2025Review
- Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children.Cell communication and signaling : CCS · 2024Article
- Salivary glands - a new site of Helicobacter pylori occurrence.Journal of applied biomedicine · 2024Article
- The role of periodontitis in cancer development, with a focus on oral cancers.Molecular biology reports · 2024Review
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- Review
- The Role of Adhesion in Helicobacter pylori Persistent Colonization.Current microbiology · 2023Review
- Review
- Worldwide Prevalence and Risk Factors ofChildren (Basel, Switzerland) · 2022Review
- Integrative Analysis of Deregulated miRNAs Reveals Candidate Molecular Mechanisms Linking H. pylori Infected Peptic Ulcer Disease with Periodontitis.Disease markers · 2022Article
- Distribution ofBiomedicines · 2020Article
- Article
- Type IV secretion ofGut pathogens · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany polymerase chain reaction (PCR)-based studies have shown that Helicobacter pylori DNA is prevalent in the oral cavity, but reports on the isolation of live bacteria are extremely rare. Thus, it is still unclear whether H. pylori can indeed survive in the oral environment.
methodsHere we used electron microscopy, selective growth techniques, urease assays, 16S rRNA PCR, and western blotting to investigate the possible presence of live H. pylori in 10 root canal and corresponding plaque samples of endodontic-infected deciduous teeth in three children.
resultsAlthough H. pylori DNA was verifiable by PCR in several plaque and root canal samples, bacterial colonies could only be grown from two root canals, but not from plaque. These colonies were unequivocally identified as H. pylori by microscopic, genetic, and biochemical approaches.
conclusionsOur findings show that root canals of endodontic-infected teeth may be a reservoir for live H. pylori that could serve as a potential source for transmission.
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Registered trials
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