ArticleThe Journal of membrane biology2012
Under construction: building the macromolecular superstructure and signaling components of an electrical synapse.
Article in The Journal of membrane biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.eLife · 2026Article
- Diverse roles of connexins in the neuro-vasculature in homeostasis and disease.Translational neuroscience · 2026Review
- Association of connexin36 with adherens junctions at mixed synapses and distinguishing electrophysiological features of those at mossy fiber terminals in rat ventral hippocampus.International journal of physiology, pathophysiology and pharmacology · 2024Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Article
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- No tight junctions in tight junction protein-1 expressing HeLa and fibroblast cells.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Connexin36 localization along axon initial segments in the mammalian CNS.International journal of physiology, pathophysiology and pharmacology · 2020Article
- ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses.Cells · 2019Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Vgsc-interacting proteins are genetically associated with pyrethroid resistance in Aedes aegypti.PloS one · 2019Article
- The interplay between electrical and chemical synaptogenesis.Journal of neurophysiology · 2018Review
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- The electrical synapse: Molecular complexities at the gap and beyond.Developmental neurobiology · 2017Review
- Heterotypic gap junctions at glutamatergic mixed synapses are abundant in goldfish brain.Neuroscience · 2015Article
- Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin.PloS one · 2015Article
- Functional alterations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons.FEBS letters · 2014Article
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
A great deal is now known about the protein components of tight junctions and adherens junctions, as well as how these are assembled. Less is known about the molecular framework of gap junctions, but these also have membrane specializations and are subject to regulation of their assembly and turnover. Thus, it is reasonable to consider that these three types of junctions may share macromolecular commonalities. Indeed, the tight junction scaffolding protein zonula occluden-1 (ZO-1) is also present at adherens and gap junctions, including neuronal gap junctions. On the basis of these earlier observations, we more recently found that two additional proteins, AF6 and MUPP1, known to be associated with ZO-1 at tight and adherens junctions, are also components of neuronal gap junctions in rodent brain and directly interact with connexin36 (Cx36) that forms these junctions. Here, we show by immunofluorescence labeling that the cytoskeletal-associated protein cingulin, commonly found at tight junctions, is also localized at neuronal gap junctions throughout the central nervous system. In consideration of known functions related to ZO-1, AF6, MUPP1, and cingulin, our results provide a context in which to examine functional relationships between these proteins at Cx36-containing electrical synapses in brain--specifically, how they may contribute to regulation of transmission at these synapses, and how they may govern gap junction channel assembly and/or disassembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.